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| Effect of specific immunotherapy on serum levels of indoleamine 2, 3-dioxygenase in children with allergic rhinitis |
| ZHENG BO, WANG Miao, NI Liyan, ZENG Yi, LIU Fanli. |
Department of Otolaryngology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027
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| Cite this article: |
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ZHENG BO,WANG Miao,NI Liyan, et al. Effect of specific immunotherapy on serum levels of indoleamine 2, 3-dioxygenase in children with allergic rhinitis[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(12): 912-915.
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Abstract Objective: To explore the effect of subcutaneous specific immunotherapy on levels of the serum indoleamine 2, 3 dioxygenase in children with allergic rhinitis. Methods: Fifty-one children with persistent moderate to severe degree allergic rhinitis were divided into SIT group and drug group according to the wishes of their families, of whom thirty-one children received SIT (SIT group) while twenty children treated with drug therapy (drug group). Serum IDO concentration of the two groups were tested before treatment and one year after treatment. Nose total nasal symptom scores (TNSS) and medication scores were recorded at each time point. Results: The serum IDO concentration of the SIT group before SIT and one year after SIT was (70.43±8.80) ng/mL
and (78.78±6.28) ng/mL, with statistically significant difference (t=5.72, P<0.01), the serum IDO concentration of the drug group before treatment and one year after treatment was (70.17±8.32) ng/mL and (69.27±6.69)ng/mL, there was no difference within this two groups (t=1.05, P>0.05). After 1 year of SIT, the TNSS and medication scores of the SIT group were reduced,the difference was significant (7.52±2.16, 4.84±1.21 vs. 4.10±1.96, 1.06±1.00, both P<0.01). After 1 year of drug treatment, the TNSS and medication scores of the drug group were also reduced (7.35±2.08, 4.60±1.76 vs. 4.35±1.23, 2.60±0.99, both P<0.01). There was no correlation (all P>0.05) between the serum IDO concentration and TNSS of two groups at each time point. Conclusion: SIT can obviously control the allergic rhinitis symptoms, resulting in reducing the use of drugs. The serum IDO levels of children with allergic rhinitis are increasing during SIT progress. IDO may play an important role in the process of immune tolerance mediated from SIT.
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Received: 31 July 2016
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