|
|
|
| Effect of mitochondrial aldehyde dehydrogenase 2 genotype on cardio-protection in patients with coronary artery bypass grafting |
| ZHANG Yujian1, DAI Yiru1,2, XIA Fangfang1, LIU Le1, XU Xuzhong1. |
1.Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Department of Anesthesiology, Chinese Traditional and Western Medicine Hospital, Wenzhou, 325000
|
|
| Cite this article: |
|
ZHANG Yujian,DAI Yiru,XIA Fangfang, et al. Effect of mitochondrial aldehyde dehydrogenase 2 genotype on cardio-protection in patients with coronary artery bypass grafting[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(12): 901-904.
|
|
|
Abstract Objective: To investigate the clinical effect of ALDH2*1 allele on cardio-protection of patients with coronary artery bypass grafting (CABG). Methods: Forty eight patients undergone simple CABG were divided into 2 group: ALDH2*1 (n=29) and ALDH2*2 (n=19), according to the results of ALDH2 gene SNP504 detection. 24 hours after operation, blood sample were taken for the measurement of cTnI, Mb, CK-MB and MDA. Postoperative mechanical ventilation time, ICU length of stay and postoperative 24 h cardiac drug use score were recorded. Results: There was no difference in the patient’s data among two groups, including age, body weight, ejection fractions and operation time. ALDH2*1 carriers showed lower cTnI, Mb, CK-MB and MDA, and shorter postoperative mechanical ventilation time, ICU length of stay and postoperative 24 h cardiac drug use score. Conclusion: ALDH2*1 allele protects against myocardium injury during open heart surgery cardiopulmonary bypass. The mechanism may be related to ALDH2 enzymes metabolism of toxic aldehydes.
|
|
Received: 14 March 2016
|
| |
|
|
|
|
|
|
