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| Expression and significance of tumor necrosis factor-alpha and interleukin-6 in juvenile nasopharyngeal angiofibroma |
| WU Xianmin1, YE Fan1, WU Peng1, CHEN Xiaoyun1, LIN Chang2, LIAO Zhisu1. |
1.Department of Otorhinolaryngology and Head and Neck Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Department of Otorhinolaryngology and Head and Neck Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350004
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| Cite this article: |
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WU Xianmin,YE Fan,WU Peng, et al. Expression and significance of tumor necrosis factor-alpha and interleukin-6 in juvenile nasopharyngeal angiofibroma[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(12): 887-890.
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Abstract Objective: To detect the expression of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in nasopharyngeal angiofibroma (JNA) and to explore the role of TNF-α and IL-6 in the mechnism of the bone destruction in JNA. Methods: The expressions of TNF-α and IL-6 in JNA tissue of 20 patients and normal inferior turbinate tissues in 10 cases of persons were determined by SP method of immunohistochemistry. Results: The positive expression rates of TNF-α and IL-6 proteins in JNA both were 90.0%, significantly higher than those in inferior turbinate tissues which both were 20.0% (P<0.01). The expressions of TNF-α and IL-6 protein were no correlation with the clinical stage of JNA (P>0.05). Conclusion: The higher expressions of TNF-α and IL-6 in JNA tissues may be the influence factors involved in bone destruction of the JNA.
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Received: 09 April 2016
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