条件性刺激诱导大鼠建立异丙酚复吸行为

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Abstract Objective: To induce rat establishing propofol relapse behavior, conditioned cues was utilized. Methods: Rats received propofol self-administration 3 h session per day for a total of 14 days under FR=1 (fixed- ratio=1) schedule. Twenty-four rats well trained for propofol self-administration were divided into 3 groups (n=8): Relapse 1 day (R1), Relapse 14 days (R14) and Relapse 30 days (R30). After withdrawal, those rats reintroduce to training-chambers for consecutive 1 hour relapse testing induced by contextual and contingent discreet conditioned cues respectively. Results: Stable propofol self-administration was established after 14 days training sessions. Compared to inactive nose-poke response, the number of active nose-poke response increased significantly (P<0.01). Compared to active nose-poke response of R1, the number of active nose-poke response of R14 increased significantly after 14 withdrawal days (P<0.01). And the number of active nose-poke response of R30 also increased after withdrawal 30 days, but there was no statistic difference compared with that of R1 (P=0.057). The number of active nose-poke response of contingent discreet conditioned cues was strongly higher than that of contextual (P<0.01). Conclusion: Propofol relapse can be induced by drug-related environmental cues, and propofol has obvious characteristics of relapse.

Key words： propofol relapse environmental cues self-administration

Received: 15 January 2016

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	WANG Benfu
	YANG Xiaowei
	LAI Miaojun
	ZHOU Wenhua
	LIAN Qingquan.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2016/V46/I12/865

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