育龄妇女接种麻疹疫苗对婴儿麻疹抗体及麻疹疫苗接种的影响

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Abstract Objective: To study the dynamic changes of the measles antibody in infants born to women who were vaccinated against measles, and to understand the effect of measles vaccination on the infants. Methods: This study was performed from January 01, 2012 to December 31, 2012 on 300 women of childbearing age. The infants born to these women were divided into the following 4 groups in a randomized and controlled trial (RCT) for measles IgG antibody detection: High antibody non-vaccination group (Group I, 52 cases), High antibody vaccination group (Group II, 53 cases), Low antibody non-vaccination group (Group III, 98 cases), and Low antibody vaccination group (Group IV, 97 cases). Group I and Group III were not vaccinated, while Group II and Group IV were vaccinated with the measles-mumps-rubella vaccine. In all cases, the expectant mothers had the IgG antibodies. All the infants showed IgG antibodies at birth and at the age of 8-and-half months and at 3 months after vaccination. Moreover, measles IgM antibody was detected within half a month after vaccination. A correlation analysis of the level of measles IgG antibody in the infants at birth and the expecting women of childbearing age was performed to study the dynamic changes in the IgG antibody and the IgM antibody levels in infants. Results: There was a significant correlation between the antibody level of the expectant women of childbearing age and the infants at birth (r=0.85). The results of repeated measures analysis showed that there were significant differences in the changes of IgG levels between Group I and III and Group II and IV (all P=0.00), while there was no significant difference between Group I and III and Group II and IV (P=0.11 and P=0.45). At 3 months after inoculation, the groups were compared and F=1.36 and P=0.26, which indicated that there was no significant difference in the time between the groups. The trend chart of IgG antibody showed that the level of infants’ measles fetal transmission antibody decreased gradually with time, and increased at 3 months after vaccination. The ratio of the IgM sample/clinical value of infant measles (S/CO value) of all the groups was analyzed by single factor analysis of variance, and no significant difference was found between each group (F=0.95, P=0.42). Conclusion: The findings of this study show that infants of women of childbearing age who undergo measles vaccination have sufficient protective antibodies before their vaccination, and these antibodies do not affect their measles vaccination.

Key words： measles women of childbearing age fetal transmission antibody vaccine

Received: 02 February 2016

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	Xia Chan
	Liu Qi
	Wen Zhengwang
	Dong Lei
	Lin Hailong

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2016/V46/I11/813

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