ERCC1、XPD、XPC单核苷酸多态性与局部晚期宫颈癌新辅助化疗敏感性的相关性

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Abstract Objective: To investigate whether single-nucleotide polymorphisms of ERCC1, XPD, XPC affected response in locally advanced cervical cancer (LACC) receiving platinum-based neoadjuvant chemotherapy (NACT). Methods: A total of 114 patients who were pathologically diagnosed as cervical carcer treated with platinum-based neoadjuvant chemotherapy were examined for genotyping of ERCC1, XPD and XPC in peripheral blood lymphocytes with the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RPLF), and than the correlation between different genotypes with NACT curative effect was analized. Results: Variant genotypes of ERCC1 Asn118Asn were significantly associated with /C genetype LACC chemosensitivity (P<0.05). To compare ERCC1 Asn118Asn C/T genetype with ERCC1 Asn118Asn C/C genetype, chemosensitivity increased 4.48 times (odds ratio 4.48; 95%CI: 1.436-13.976; P<0.05). While no significant difference was found between chemotherapy response and SNPs of XPD condon 751 and XPC condon 939 (P>0.05). Conclusion: Our study provides evidence for the predictive role of ERCC1 Asn118Asn on chemotherapy response in LACC patients treated with.

Key words： locally advanced cervical cancer neoadjuvant chemotherapy polymorphism

Received: 04 January 2016

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	QI Lifang
	LYU Jieqiang
	ZHU Xueqiong
	XIA Lu
	HUANG Qiusui
	QU Wanglei
	CHEN Wenbing.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2016/V46/I10/724

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