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Clinical study of recombinant human endostatin combined with hepatic arterial chemoembolization in advanced primary hepatic carcinoma |
ZHAO Jianguo1, WANG Ting1, ZHAO Zhongwei2, YE Wanli1, WU Dongping1, JI Jiansong2, WANG Jianfang1 |
1.Department of Oncology, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, 312000; 2.Department of Radiology, Lishui Central Hospital, Lishui, 323000
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Cite this article: |
ZHAO Jianguo,WANG Ting,ZHAO Zhongwei, et al. Clinical study of recombinant human endostatin combined with hepatic arterial chemoembolization in advanced primary hepatic carcinoma[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(4): 245-248.
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Abstract Objective: To investigate the clinical efficacy and adverse reactions of recombinant human endostatin (Endostar) combined with transcatheter arterial chemoembolization (TACE) in advanced hepatocellular carcinoma (aHCC) and provide the reference treatment for aHCC. Methods: Sixty-two patients with advanced hepatocellular carcinoma were enrolled from January 2011 to December 2014 in our hospital which were divided randomly into observation group (32 cases) and control group (30 cases) according to the therapeutic methods, the patients of control group were treated with TACE, while the observation group was treated with TACE combined with hepatic dynamic arterial infusion of Endostar. The clinical efficacy and adverse reactions were observed and evaluated between two groups after treatment. Results: The effective rate of observation group was 75%, which was significantly higher than that of the control group with 46.67% (P<0.05), the PFS of observation group was significantly longer than the control group (P<0.05), the survival time was not significantly different (P>0.05) in two groups. No significant difference was found in the incidence of adverse reactions between two groups (P>0.05). Conclusion: Endostar combined with TACE can effectively improve the clinical efficacy and prolong the PFS without more adverse reactions in aHCC, which has important clinical value.
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Received: 08 October 2015
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