MIF基因多态性与剖宫产术后腹壁子宫内膜异位症遗传易感性相关性研究

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Abstract Objective: To investigate whether polymorphisms of macrophage migration inhibitory factor (MIF) in promoter region (rs2012133G/C, rs4822443A/G and rs4822446G/A) are associated with hereditary susceptibility of abdominal wall endometriosis after cesarean section. Methods: Sixty patients with abdominal wall endometriosis after cesarean section were selected as case group and 109 healthy volunteers were collected as control group. The genotypes were detected by polymorphism chain reaction and restriction fragment length polymorphism analysis (PCR-RFLP). Results: There were statistical differences in genotype frequencies and allele frequencies between the case group and the control group (P=0.032; P=0.031) in rs2012133G/C site, GG genotype may markedly increase the risk of abdominal wall endometriosis after cesarean section (OR=2.284, 95%CI: 1.200～4.345). While no significant statistical differences could be found in rs4822443A/G, rs4822446G/A sites (P>0.05). Conclusion: The results suggest that MIF rs2012133G/C polymorphism is associated with abdominal wall endometriosis after cesarean section, GG genotype is the risk genotype.

Key words： endometriosis macrophage migration inhibitory factor polymorphism cesarean section

Received: 09 December 2015

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	LIN Rongrong
	GU Hangzhi
	ZHOU Xinxin
	ZHENG YUNFEI

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2016/V46/I3/178

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