|
|
|
| Expression and clinical significance of ultra early stage biomarker blood β-actin in patient with acute cerebral infarction |
| ZHANG Yaping, WANG Binda, LIU Chunyan, YE Zhinan, TANG Weiguo, WU Zhouna, HE Songbin. |
Department of Neurology, Zhoushan Hospital Affiliated to Wenzhou Medical University, Zhoushan, 316000
|
|
| Cite this article: |
|
ZHANG Yaping,WANG Binda,LIU Chunyan, et al. Expression and clinical significance of ultra early stage biomarker blood β-actin in patient with acute cerebral infarction [J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(3): 174-177.
|
|
|
|
Abstract Objective: To explore the expression level of blood β-actin and its clinical significance in ultra early stage of acute cerebral infarction. Methods: Eighty patients with acute cerebral infarction (ACI) were selected as cerebral infarction group, and they were divided into five subgroups by different periods (2 hours, 4 hours, 6 hours, 24 hours and 72 hours), 16 patients in each subgroup. Other 48 cases without cerebral infarction were selected as control group, including 16 cases of transient ischemic attack, 16 cases of cerebral hemorrhage and 16 cases of healthy contrast group. The content of blood β-actin was detected by enzyme-linked immunosorbent method and analyzed combined with clinical condition. Results: ①The content of blood β-actin in the cerebral infarction group was significantly higher than those in the control group (P<0.05). ②The diagnostic kit for ACI was determined at 2.10 ng/mL by ROC curve. It had high sensitivity and specificity. ③The level of blood β-actin in patients with acute cerebral infarction has certain correlation with the area of cerebra1 infarction as well as NIHSS scores. Conclusion: The elevated level of blood β-actin may be a practical biomarker of acute cerebral infarction in ultra early stage.
|
|
Received: 25 July 2015
|
| |
|
|
|
[1] 全国第四届脑血管病学术会议. 脑卒中患者临床神经功能损伤程度评分标准及临床疗效评定标准[J]. 中华神经科杂志, 1996, 29(6): 381-383.
[2] LABORDE C M, MOURINO-ALVAREZ L, AKERSTROM F, et al. Potential blood biomarkers for stroke[J]. Expert Rev Proteomics, 2012, 9(4): 437-449.
[3] JICKLING G C, SHARP F R. Blood biomarkers of ischemic stroke[J]. Neurotherapeutics, 2011, 8(3): 349-360.
[4] MIAO Y, LIAO J K. Potential serum biomarkers in the pathophysiological processes of stroke[J]. Expert Rev Neurother, 2014, 14(2): 173-185.
[5] CARDOSO F L, BRITES D, BRITO M A. Looking at the blood-brain barrier: Molecular anatomy and possible investigation approaches[J]. Brain Res Rev, 2010, 64(2): 328-363.
[6] WITT K A, MARK K S, HOM S, et al. Effects of hypoxiareoxygenation on rat blood-brain barrier permeability and tight junctional protein expression[J]. Am J Physiol Heart Circ Physiol, 2003, 285(6): H2820-H2831.
[7] AN P, XUE Y X. Effects of preconditioning on tight junction and cell adhesion of cerebral endothelial cells[J]. Brain Research, 2009, 1272: 81-88.
[8] BROWN R C, DAVIS T P. Hypoxia/aglycemia alters expression of occludin and actin in brain endothelial cells [J].Biochern Biophys Res Commun, 2005, 327(4): 1114-1123.
[9] SANDOVAL K E, WITT K A. Blood-brain barrier tight junction permeability and ischemic stroke[J]. Neurobiol Dis, 2008, 32 (2): 200-219.
[10] 房春燕, 代允义, 宋兴伟, 等. 低O2高CO2对小鼠血脑屏障及水通道蛋白-4表达的影响[J]. 温州医学院学报, 2009, 39(2): 104-107.
[11] 王波, 徐家丽. 脑缺氧缺血后血脑屏障通透性改变及其机制研究进展[J]. 国际儿科学杂志, 2011, 38(6): 620-623.
[12] 饧赞章, 陈虹, 闫明俞, 等. 大鼠急性脑缺血后血脑屏障通透性变化的实验研究[J]. 中华中医药学刊, 2009, 27(3): 501-503.
[13] JIN X, LIU J, YANG Y, et al. Spatiotemporal evolution of blood brain barrier damage and tissue infarction within the first 3h after ischemia onset[J]. Neurobiol Dis, 2012, 48(3): 309-316.
[14] 许楠, 曹非. 脑出血后血脑屏障损害研究进展[J]. 中国卒中杂志, 2015, 10(2): 181-186.
|
|
|
|
