微囊化胰岛移植联合肾动脉重建缓解糖尿病肾病大鼠早期肾脏病变

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Abstract Objective: To establish rat’s model of transplantation of microencapsulated islets combined with renal arterial reconstruction and observe the curative effect of this model on the renal pathology in the early stage for the diabetic nephropathy in rats. Methods: Rat model of diabetes established by injection of a single dose of streptotocin were randomized into diabetic nephropathy (DN) group, microencapsulated islets group and combination group. After 4 weeks, 24 h proteinuria and random blood glucose level of all rats were examined, and pathological changes of the kidney and renal artery were observed under optical microscope. Results: Compared with DN group, blood glucose level and 24 h proteinuria in combination group was significantly lower. Microencapsulated islets group and combination group significantly alleviated glomerulosclerosis compared to DN group. However, there was no significant difference in the glomerulosclerosis between microencapsulated islets group and combination group. In addition, the intimal thickness of renal artery between micro-encapsulated islets group and combination group was not obvious. Conclusion: Microencapsulated islets combined with renal artery reconstruction can improve early stage renal pathology in DN rats.

Key words： transplantation, Langerhans of islets diabetic nephropathy glomerulosclerosis rats

Received: 09 July 2015

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	XU Ziqiang
	HE Yunqiang
	FU Hongxing
	XU Yanyan
	CAI Yong
	XIA Peng

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2016/V46/I3/163

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