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| Clinical value of fetal prenasal thickness examination with ultrasonograpy to scann Down syndrome |
| YE Feng1, DONG Xueqin1, BAI Lili1, NI Jiana1, XU Xueqin2, CHEN Limin1. |
1.Department of Ultrosonograpy, Dingli Clinical Hospital of Wenzhou Medical University, Central Hospital of Wenzhou, Wenzhou, 325000; 2.Department of Clinical Laboratory, Dingli Clinical Hospital of Wenzhou Medical University, Central Hospital of Wenzhou, Wenzhou, 325000
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| Cite this article: |
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YE Feng,DONG Xueqin,BAI LilI, et al. Clinical value of fetal prenasal thickness examination with ultrasonograpy to scann Down syndrome[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(2): 129-132.
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Abstract Objective: To construct a reference range for fetal prenasal thickness of second trimester fetuses with prenatal ultrasonograpy and to explore the relationship between the thickness in fetuses with Down syndrome. To evaluate the clinical value of prenasal thickness in scanning Down syndrome. Methods: The fetal profile was acquired from 597 normal fetuses and 46 fetuses with trisomy 21 at 16～25 weeks’ gestation between February 2012 and February 2014. Two-dimensional ultrasound was used to obtain the exact mid-sagittal plane and the prenasal thickness between the anterior edge of the lowest part of the frontal bone (at the junction with the nasal bone when present) and the skin anteriorly. Results: In the normal group prenasal thickness increased with gestation from a mean of (2.2± 0.4) mm at 16 weeks to (4.7±0.5) mm at 25 weeks (r=0.725, P<0.001). In 32 (69.6%) cases of the trisomy-21 fetuses the prenasal thickness was above the 95th centile of the normal range. When prenasal thickness above the 95th centile of the normal range was used as a cut-off, the sensitivity for Down syndrome. was 69.6%, the specificity was 96.3%, the positive predictive value was 64.0%, the negative predictive value was 97.1%, the positive likelihood ratio was 19.0, the negative likelihood ratio was 0.32. Conclusion: Increased prenasal thickness is a high risk for DS and can be used as a prenatal ultrasonographic mark in scanning Down syndrome.
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Received: 18 May 2015
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