年龄及卵巢刺激对卵子利用率的影响

Abstract
Figure/Table
References (0)
Related Citation (0)

Download: PDF (1509 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To explore the effect of live birth per cycle, number of live births per mature oocyte and the number of mature oocytes per live birth according to ovarian ageing and ovarian response. Methods: A total of 1637 ICSI-ET cycles from January 2012 to February 2014 in Reproductive Medicine Center of the First Affiliated Hospital of Wenzhou Medical College were retrospectively analyzed. Live birth per cycle, number of live births per mature oocyte and number of mature oocytes per live birth were further analysed in relation to the age or ovarian response. The clinical outcomes were compared. Results: The data presented in this study showed that the number of live births per mature oocyte and the number of oocytes per live birth remained remarkably stable between the age of 23 and 37 years. After the age of 37 years number of live births per mature oocyte began to decrease gradually but from 40 years of age it dropped dramatically, and the number of mature oocytes per live birth increased. On the other hand, the pregnancy rate per cycle increased with the number of retrieved oocytes, so the pregnancy rate per cycle was highly dependent on ovarian response. Compared between the three ovarian response group, number of live births per mature oocyte was lower (P<0.01) and the the number of oocytes per live birth was higher (P<0.01) in the response group with more mature oocytes, which indicated that the ovarian stimulation might affect the reproductive potential of the individual oocyte. Conclusion: These data are extremely valuable as they provide information on the expected outcome in women undergoing fertility preservation. Moreover, it is crucial in the prediction of IVF success and patient counseling and considering the launching oocyte freezing for fertility preservation in our center.

Key words： live birth per mature oocyte live birth rate per cycle intracytoplasmic sperm injection fertility preservation

Received: 24 April 2015

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHENG Yi
	WANG Haiqing
	ZHOU Ying.

URL:

https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2016/V46/I2/112

[1] Practice Committees of American Society for Reproductive Medicine, Society for Assisted Reproductive Technology.Mature oocyte cryopreservation: a guideline[J]. Fertil Steril, 2013, 99(1): 37-43.
[2] COBO A, REMOHÍ J, CHANG C C, et al. Oocyte cryopreservation for donor egg banking[J]. Reprod Biomed Online, 2011, 23(3): 341-346．
[3] RIENZI L, COBO A, PAFFONI A, et al. Consistent and predictable delivery rates after oocyte vitrification: an observational longitudinal cohort multicentric study[J]. Hum Reprod, 2012, 27(6): 1606-1612.
[4] CAI L B, QIAN X Q, WANG W, et al. Oocyte vitrification technology has made egg-sharing donation easier in China [J]. Reprod Biomed Online, 2012, 24(2): 186-190．
[5] SUNKARA S K, RITTENBERG V, RAINE-FENNING N, et al. Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles[J]. Hum Reprod, 2011, 26(7): 1768-1774.
[6] PATRIZIO P, SAKKAS D. From oocyte to baby: a clinical evaluation of the biological efficiency of in vitro fertilization [J]. Fertil Steril, 2009, 91(4): 1061-1066.
[7] KOVALEVSKY G, PATRIZIO P. High rates of embryo wastage with use of assisted reproductive technology: a look at the trends between 1995 and 2001 in the United States[J].Fertil Steril, 2005, 84(2): 325-330.
[8] INGE G B, BRINSDEN P R, ELDER K T. Oocyte number per live birth in IVF: were Steptoe and Edwards less wasteful?[J]. Hum Reprod, 2005, 20(3): 588-592.
[9] STOOP D, ERMINI B, POLYZOS N P, et al. Reproductive potential of a metaphase II oocyte retrieved after ovarian stimulation: an analysis of 23354ICSI cycles[J]. Hum Reprod, 2012, 27(7): 2030-2035.
[10] PATRIZIO P, BIANCHI V, LALIOTI M D, et al. High rate of biological loss in assisted reproduction: it is in the seed, not in the soil[J]. Reprod Biomed Online 2007, 14(1): 92-95.
[11] EDGAR D H, GOOK D A. How should the clinical efficiency of oocyte cryopreservation be measured?[J]. Reprod Biom Online, 2007, 14(4): 430-435.
[12] REDIG A J, BRANNIGAN R, STRYKER S J, et al. Incorporating fertility preservation into the care of young oncology patients [J]. Cancer, 2011, 117(1): 4-10.
[13] 陈士玲, 罗燕群, 夏容, 等. 女性年龄与不孕及生育力减退[J]. 国际生殖健康/计划生育杂志, 2011, 30(4): 265-271.
[14] 周颖, 黄学锋, 叶碧绿, 等. 体外受精-胚胎移植中胚胎质量和女方年龄与多胎妊娠的相关性[J]. 温州医学院学报, 2004, 34(2): 111-113.
[15] Committee on Gynecologic Practice of American College of Obstetricians and Gynecologists, Practice Committee of American Society for Reproductive Medicine. Age-related fertility decline: a committee opinion[J]. Fertil Steril, 2008, 90(5 Suppl): S154-155.
[16] JANSEN R, MORTIMER D. Towards reproductive certainty: infertility and genetics beyond 1999[M]. Tennessee Nashville: Parthenon Press, 1999: 196.
[17] BENTOV Y, ESFANDIARI N, BURSTEIN E, et al. The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients[J]. Fertil Steril, 2010, 93(1): 272-275.
[18] CALIGARA C, NAVARRO J, VARGAS G, et al. The effect of repeated controlled ovarian stimulation in donors[J]. Hum Reprod, 2001, 16(11): 2320-2323.
[19] FADDY M J, GOSDEN R G. A mathematical model of follicle dynamics in the human ovary[J]. Hum Reprod, 1995, 10(4): 770-775.
[20] 梁晓燕, 李轶, 杜静, 等. 反复控制性卵巢刺激对卵巢功能状态的影响[J]. 中山大学学报(医学科学版), 2008, 29 (2): 186-189.
[21] MENIRU G I, CRAFT I L. Utilization of retrived oocytes as an index of the efficiency of superovulation strategies for invitro fertilization treatment[J]. Hum Reprod, 1997, 12(10): 2129-2132.
[22] BAART E B, MARTINI E, EIJKEMANS M J, et al. Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial[J]. Hum Reprod, 2007, 22(4): 980-988.
[23] WANG X, CHEN C, WANG L, et al. Conception, early pregnancy loss, and time to clinical pregnancy: a population based prospective study[J]. Fertil Steril, 2003, 79(3): 577-584.