维生素D与COPD患者肺功能及血清炎症因子的相关性

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Abstract Objective: To investigate the relationship between vitamin D and pulmonary function and serum inflammatory factors in patients with COPD. Methods: Twenty-seven healthy subjects, 30 patients with stable COPD and 34 patients with acute exacerbations of COPD were enrolled in our study. Serum level of 25-(OH)D was measured by the ECLIA. The expression of INF-γ and TNF-α were measured by ELISA, and IL-2, IL-4, IL-6, IL-10 were measured by FCM. All these subjects were compared among three groups. All patients of three groups performed pulmonary function tests. Correlations between 25-(OH)D and FEV1, INF-γ, TNF-α and IL-2, IL-4, IL-6, IL-10 were analyzed in stable COPD group and AECOPD group. Results: ①The levels of 25-(OH)D in AECOPD group and stable COPD group were significantly lower than those in control group (P<0.001). The level of 25-(OH)D in AECOPD group was significantly lower than that in stable COPD group (P<0.001). ②The prevalence of Vitamin D deficiency of AECOPD group and stable COPD group were higher than that of the control group (P<0.001), but there was no significant difference between AECOPD group and stable COPD (P=0.225). ③The level of 25-(OH) D was positively correlated with FEV1 in stable COPD group (r=0.524, P=0.005). ④The level of INF-γ of AECOPD group was significantly higher than those in stable COPD group (P<0.001). The level of INF-γ and IL-6 of AECOPD group was significantly higher than those in control group (both P<0.001). The level of IL-2 and IL-6 of stable COPD group was significantly higher than those in control group (P=0.024, P=0.007, respectively). ⑤There was no linear correlation between the level of 25-(OH) D and INF-γ, TNF-α, IL-2, IL-4, IL-6, IL-10 in patients with COPD. Conclusion: Vitamin D deficiency is highly prevalent to COPD patients, and the level of 25-(OH) D may be positively correlated with FEV1, but there was no linear correlation between the level of 25-(OH) D and serum inflammatory factors in patients with COPD.

Key words： COPD 25-(OH)D FEV1 inflammatory factors

Received: 02 July 2015

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	JIANG Huanhuan
	DAI Yuanrong

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2016/V46/I2/102

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