PSMA6基因rs1048990位点多态性与动脉粥样硬化性脑梗死的相关性分析

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Abstract Objective: To investigate the correlation between rs1048990(-8C/G) polymorphism of proteasome subunit alpha type 6(PSMA6) gene and artery atherosclerosis cerebral infarction in Han population of the Shanxi province in China. Methods: By using a case-control method, 162 patients with artery atherosclerosis cerebral infarction (the case group) and 159 healthy controls over the same period (the control group) were selected in the study. The patients were in hospital of the department of neurology in the Affiliated Hospital of Xi’an Medical College from January 2012 to December 2013. The single nucleotide polymorphism of rs1048990 of PSMA6 gene was identified by the polymerase chain reaction (PCR) and restriction fragment length polymorphism(RFLP), and genotype and allele frequency distributions in cerebral infarction patients and healthy controls were analyzed. Results: Compared with the control group, the difference of the frequency of GG genetype in the the case group wasn’t significant (P=0.054), the difference of the frequency of G allele wasn’t significant, either (P=0.05). After stratified by suffering from high blood pressure and diabetes, respectively, we didn’t find significant differences among all genotypes and alleles in the case group (all P>0.05); the same result had been found in the control group, too. After adjustment for known cerebral vascular risk factors by logistic regression analysis, the GG genotype of rs1048990 revealed no statistical significance between the case group and the control group (P=0.059). Conclusion: The rs1048990 of PSMA6 gene mayn’t be associated with the artery atherosclerosis cerebral infarction. But the P value approximate statistical significance, the single nucleotide polymorphism is worth further researches.

Key words： proteasome subunit alpha type 6 single nucleotide polymorphism artery atherosclerosis cerebral infarction

Received: 03 June 2015

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	ZHAO Xiyao
	HE Fangmei

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2016/V46/I2/97

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