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| Expression of CD147 and Survivin in renal cell carcinoma and their correlation with clinicopathologic parameters |
| LUO Huarong1, KE Mang2, ZHOU Tao1, XU Cheng1, BAO Weiguang3. |
1.Department of Pathology,Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou, 317000; 2.Department of Urology, Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou, 317000; 3.Human Tissue Bank, Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou, 317000
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| Cite this article: |
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LUO Huarong,KE Mang,ZHOU Tao, et al. Expression of CD147 and Survivin in renal cell carcinoma and their correlation with clinicopathologic parameters[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(1): 56-60.
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Abstract Objective: To investigate the expression of CD147 and Survivin in human renal cell carcinoma(RCC) and their correlation with clinicopathologic parameters. Methods: The RCC tissue microarrays containing 85 renal cell carcinoma specimens and 35 normal kidney tissue specimens were used to detect CD147 and Survivin expression by immunohistochemistry. Results: The expression rates of CD147 and Survivin were 65.7%(23/35) and 71.4% (25/35) in RCC group, respectively, significantly higher than that in control group (P<0.01).The expression of CD147 in RCC increased with the size of tumor and pathological grade (P<0.05). And the expression of Survivin in RCC increased with the pathological grade and clinical stage (P<0.05). The expression of CD147 and Survivin in RCC specimens showed weak consistency (Kappa=0.388, P<0.05). Multivariate logistic regression analysis showed that the positive expression of Survivin was an independent risk factor of RCC (oR=16.256, 95%CI: 1.132~ 233.515, P<0.05). Conclusion: CD147 and Survivin are over-expressed in
RCC specimens. CD147 and Survivin may play a crucial stage in development of human RCC. Detection of the expression of CD147 and Survivin can be used in the evaluation of malignant degree and prognosis of RCC.
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