|
|
|
| Changes of plasma neuroglobin and S-100β protein concentration in patients undergone coronary artery bypass grafting surgery under cardiopulmonary bypass |
| MIAO Jianxia, WANG Liangrong, ZHAO Xiyue, |
Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou,325015
|
|
|
|
Abstract Objective: To investigate the changes of plasma neuroglobin and S-100β protein concentrations in patients undergone coronary artery bypass grafting surgery under cardiopulmonary bypass (CPB). Methods:Forty patients, American Association of Anesthesiologists (ASA) and New york Heart Association (NyHA) status II or III, the Mini-Mental State Examination (MMSE, range 0～30) score≥26, undergoing coronary artery bypass grafting surgery with CPB were enrolled. Blood samples were collected immediately at anesthesia induction (T0), CPB re-warming to 36 ℃ (T1) and 1 h (T2), 6 h (T3) and 24 h (T4) after CPB, plasmas were obtained for further determination of neuroglobin and S-100β protein concentration. MMSE were measured preoperatively
and three days after operation. Results: Compared with values in T0, the plasma concentrations of neuroglobin and S-100β protein was significantly increased at T2-T4 (P<0.05), with peaking at T3. MMSE scoring at 3 d after operation was lower than preoperative baseline (P<0.05). Conclusion: Cognitive function is impaired and the plasma neuroglobin and S-100β protein levels are increased in patients undergone coronary artery bypass grafting surgery under CPB, these two can be considered as indicators of cerebral injury after cardiopulmonary bypass.
|
|
|
| |
|
|
|
|
|
|
