脑梗死伴颅内动脉狭窄与胰岛素抵抗的关系

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Abstract Objective: To evaluate the relationship between insulin resistance and intracanial arterial stenosis in patients with cerebral infarction. Methods: Two groups were studied: ①161 patients with potential intracanial arterial stenosis (grade≥50%, at least one vessel); ②81 subjects without intracanial arterial stenosis (grade<50%). Insulin resistance was determined by the steady state model evaluation method, special tool was used to calculate the evaluation index of insulin resistance. MRI and MRA was performed in all subjects. The severity of intracanial arterial stenosis was determined by the Warfarin-Aspirin Symptomatic Intracranial Disease Study (WASID). Results: The homeostasis model assassment 2-insulin resistance (HOMA2-IR) was significantly higher in patients with intracanial arterial stenosis compared with control subjects. Based on logistic regression model, high HOMA2-IR was one of the risk factors. Conclusion: These results suggest that insulin resistance is a risk for intracranial arterial stenosis.

Key words： intracanial arterial stenosis insulin resistance homeostasis model assassment 2-insulin resistance

Received: 05 May 2015

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	WANG Xiangyun
	YIN Weiyong
	ZHOU Chengye.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I12/899

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