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| Report a pedigree of familial lung cancer |
1.Department of Respiratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Department of Lab Center of Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 3.Department of Pathology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015
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Abstract Objective: To investigate the clinical iconographic characteristic, molecular patbologic test results and probable inherit susceptibility gene in a pedigree of familial aggregative lung cancer. Methods: According to family history of the proband, the pedigree was surveyed and the clinical characteristics of five cases of lung cancer in two generations who were admitted to our hospital was retrospectively analyzed. Four tumor samples and three normal lung tissues after surgery were send for molecular pathology test. A peripheral blood samples of 9 persons also send for molecular pathology examination. Results: Four persons of the second generation were diagnosed as lung cancer. And the first generation, mother was non-smoking and was confirmed with advanced adenocarcinoma and died. Three of children were diagnosed as adenocarcinoma in early stage and underwent surgery, another patient who had been in foreign country for more than 15 years and smoking, was diagnosed as small cell lung cancer, and died. Tumor samples from proband was tested with EGFR21 L858R mutation, Tumor samples from II1 and II2 had EGFR21 E868D mutation, other samples and blood samples were negative of T790M. Conclusion: As the literature reports, the mother suffering from lung cancer, the incidence of lung cancer increased, adenocarcinoma is the most common pathologic type, without germline EGFR gene T790M mutations.
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Received: 03 March 2015
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