线粒体乙醛脱氢酶2突变型基因的心肌保护作用

Abstract
Figure/Table
References (0)
Related Citation (9)

Download: PDF (1431 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To investigate the protection of human mitochondrial aldehyde dehydrognase 2 gene mutations for patients undergone cardiopulmonary bypass (CPB). Methods: A prospective cohort of TOF patients (n=71) was recruited to investigate the influence of the ALDH2*2 allele on cardio-protection after surgical repair. The patients were divided into 2 groups: ALDH2*2 (n=45) and ALDH2*1 (n=26). The right atrial appendage was harvested. ALDH2 activity, MDA and GSH were analysed. The cTnI was tested 20 hours later after the surgery. The time in hospital were recorded. Results: ALDH2*2 carriers showed highter GSH. ALDH2*2 carriers showed lower MDA, cTnI, and shorter postoperative length of hospital stay. Conclusion: ALDH2*2 allele has a myocardial protection effect after ischemic reperfusion injury, it may associated with greater expression of GSH level.

Key words： human mitochondrial aldehyde dehydrogenase 2 cardiopulmonary bypass ischemic reperfusion injury myocardial protection

Received: 07 April 2015

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Yujian1
	2
	JIN Zhousheng1
	CHEN Hongfei1
	WU Yiquan1
	XU Xuzhong1.

URL:

https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I12/883

[1] Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics—2011 update: a report from the American Heart Association[J]. Circulation, 2011, 123(4): e18-e209.
[2] Hill BG, Bhatnagar A. Beyond reactive oxygen species: aldehydes as arbitrators of alarm and adaptation[J]. Circ Res,2009, 105(11): 1044-1046.
[3] Churchill EN, Disatnik MH, Mochly-Rosen D, et al. Timedependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of εPKC and activation of aldehyde dehydrogenase 2[J]. J M Cell Cardiol, 2009, 46(2): 278-284.
[4] Contractor H, Støttrup NB, Cunninqton C, et al. Aldehyde dehydrogenase-2 inhibition blocks remote preconditioning in experimental and human models[J]. Basic Res Cardiol, 2013, 108(3): 343.
[5] Brooks PJ, Enoch MA, Goldman D, et al. The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption[J]. PLoS Med, 2009, 6(3): e50.
[6] Budas GR, Disatnik MH, Mochly-Rosen D. Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?[J]. Trends Cardiovasc Med, 2009, 19(5): 158-164.
[7] 张裕坚, 龚丁旭, 陈伟, 等. 线粒体乙醛脱氢酶基因突变型对人心肌缺血再灌注损伤的保护作用[J]. 温州医学院学报, 2011, 41(4): 340-342.
[8] 唐纯志, 赖新生, 杨君军, 等. 电针对老年性痴呆大鼠脑内SOD、MDA、GSH-Px影响的实验研究[J]. 陕西中医, 2005, 26 (2): 180-181.
[9] Chen CH, Budas GR, Churchill EN, et al. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart[J]. Science, 2008, 321(5895): 1493-1495.
[10] Endo J, Sano M, Katayama T, et al. Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart[J]. Circ Res, 2009, 105 (11): 1118-1127.
[11] Hill BG, Bhatnaqar A. Beyond reactive oxygen species: aldehydes as arbitrators of alarm and adaptation[J]. Circ Res,2009, 105(11): 1044-1046.
[12] Eaton P, Li JM, Hearse DJ, et al. Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart[J]. Am J Physiol, 1999, 276(3 Pt 2): H935-943.
[13] Singh A, Lee KJ, Lee CY, et al. Relation between myocardial glutathione content and extent of ischemia-reperfusion injury [J]. Circulation, 1989, 80(6): 1795-1804.
[14] Ahn KT, Choi JO, Lee GY, et al. Usefulness of high-sensitivity troponin I for the monitoring of subclinical acute cellular rejection after cardiac transplantation[J]. Transplant Proc, 2015, 47(2): 504-510.
[15] 赵曙光, 赵子牛, 倪乐丹, 等. 体外循环温度对冷晶体停搏液心肌保护效果的影响[J]. 温州医学院学报, 2002, 32(4):233-234.