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| Association between CACNB2 gene polymorphism and stroke of ethnic Han Chinese in Wenzhou region#br# |
1.Department of Clinical Laboratory, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027; 2.Department of Internal Neurology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027; 3.University of Florida, USA Florida, 32610; 4.Department of Clinical Laboratory, Yuhuangding Hospital, Yantai, 264000
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WANG Xin1,4,CHEN Jing1, et al. Association between CACNB2 gene polymorphism and stroke of ethnic Han Chinese in Wenzhou region#br#[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(12): 869-.
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Abstract Objective: To explore the association between genetic polymorphism of CACNB2 and stroke of ethnic Han Chinese in Wenzhou region. Methods: Four hundred and thirteen cases of essential hypertension (EH), 418 cases of high blood pressure with ischemic stroke, 377 cases of high blood pressure with hemorrhagic stroke and 355 normal controls were analyzed via cross-sectional case-control. Six SNP loci of genotypes of rs11014166, rs10764319, rs7099380, rs7069292, rs2228645, rs2357928 of CACNB2 were typed by MALDI-TOFMS. Results: Compared to the control, the frequency of the CT genotype and allele frequency C of rs7069292 in high blood pressure group, high blood pressure with ischemic stroke group and high blood pressure with hemorrhagic stroke group were significantly higher (the frequency of the CT genotype 6.05% vs 1.97%, 6.94% vs 1.97%, 6.36% vs 1.97%, allele frequency C 3.03% vs 1.0%, 3.47% vs 1.0%, 3.18% vs 1.0%, P<0.05). There was no significant difference in the other 5 SNPs, P>0.05. Conclusion: There is significant association between polymorphisms of CACNB2 and people with essential hypertension (EH) in Wenzhou region. T>C may be a factor that affected the gene expression of CACNB2 and lead to high blood pressure. Mutation of T>C has no relevance with stroke by correcting the influence of high blood pressure.
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Received: 11 April 2014
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