|
|
|
| The role of RAGE-ROS axis in the apoptosis of gingival fibroblast in diabetic periodontitis |
| HUANG Shengbin, DAI Panpan, MAO Yixin, LI Xumin, MA Jianfeng. Department of Prosthodontics, Hospital of Stomatology Wenzhou Medical University, Wenzhou, 325027 |
|
| Cite this article: |
|
Shengbin,DAI Panpan,MAO Yixin, et al. The role of RAGE-ROS axis in the apoptosis of gingival fibroblast in diabetic periodontitis[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(12): 864-.
|
|
|
|
Abstract Objective: To investigate the role of RAGE-ROS axis in the apoptosis of gingival fibroblast in diabetic periodontitis. Methods: Thirty wistar rats (male, six weeks old) were randomly divided into two groups: normal control group (N) and diabetic periodontitis group (D). Four weeks later, animals were sacrificed; meanwhile, the alveolar bone loss and apoptosis of gingival fibroblast were detected while the expression of RAGE and oxidative stress marker were also investigated. Results: Compared to N group, more severe alveolar bone loss, along with more apoptosis of gingival fibroblast appeared in D group (P<0.05). The expression of RAGE and oxidative stress marker increased significantly in gingival tissue in D group (P<0.05). Conclusion: RAGE-ROS axis plays an important role in the apoptosis of gingival fibroblast in diabetic periodontitis.
|
|
Received: 16 November 2015
|
| |
|
|
|
[1]Taylor JJ, Preshaw PM, Lalla E. A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes[J]. Clin J Periodontol, 2013, 40 suppl 14: S113-134.
[2]Desta T, Li J, Chino T, et al. Altered fibroblast proliferation and apoptosis in diabetic gingival wounds[J]. J Dent Res,2010, 89(6): 609-614.
[3]International Diabetes Federation. (2012) IDF Diabetes Atlas[R]. 5th ed. International Diabetes Federation, 2012.
[4]Cipollone F, Iezzi A, Fazia M, et al. The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control[J]. Circulation, 2003, 108(9): 1070-1077.
[5]Ramasamy R, Vannucci SJ, Yan SS, et al. Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation[J]. Glycobiology, 2005, 15(7): 16-28.
[6]Katz J, Bhattacharyya I, Farkhondeh-Kish F, et al. Expression of the receptor of advanced glycation end products in gingival tissue of type 2 diabetes patients with chronic periodontal disease: a study utilizing immunohistochemistry and RT-PCR[J]. J Clin Periodontol, 2005, 32(1): 40-44.
[7]Thomas MC, Forbes JM, Cooper ME. Advanced glycation end products and diabetic nephropathy[J]. Am J Ther, 2005, 12(6): 562-572.
[8]Schmidt AM, Weidman E, Lalla E, et al. Advanced glycation end products (AGEs) induce oxidant stress in the gingiva: a potential mechanism underlying accelerated periodontal disease associated with diabetes[J]. J Periodontal Res, 1996, 31 (7): 508-515.
[9]Takeda M, Ojima M, Yoshioka H, et al. Relationship of serum advanced glycation end products with deterioration of periodontitis in type 2 diabetes patients[J]. J Periodontol, 2006, 77(1): 15-20.
[10]Govindaraj P, Khan NA, Gopalakrishna P, et al. Mitochondrial dysfunction and genetic heterogeneity in chronic periodontitis [J]. Mitochondrion, 2011, 11(3): 504-512.
[11]Graves DT, Liu R, Alikhani M, et al. Diabetes enhanced inflammation and apotosis-impact on periodontal pathology[J]. J Dent Res, 2006, 85(1): 15-21.
[12]付永伟, 和红兵, 欧炯光. 实验性糖尿病牙周炎诱导骨细胞凋亡的初步研究[J]. 现代口腔医学杂志, 2009, 23(5): 500-504.
[13]付永伟, 和红兵, 欧炯光. 实验性糖尿病牙周炎牙周膜中成纤维细胞凋亡的初步研究[J]. 实用口腔医学杂志, 2010, 26(3): 310-314.
[14]邓天政, 吕晶, 逢键梁, 等. 细胞凋亡在糖尿病大鼠牙周炎中参与牙槽骨吸收的实验研究[J]. 北京口腔医学, 2010, 18(5): 257-260. |
|
|
|
