男性酒精依赖患者认知功能与红细胞参数的相关性分析

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Abstract Objective: To investigate whether male alcohol-dependent patients had cognitive impairments, and cognitive impairments were correlated with erythrocyte parameters in male alcohol-dependent patients. Methods: Sixty adults male, including 30 alcohol-dependent patients and 30 healthy controls in Wenzhou Kangning Hosipital Affiliated to Wenzhou Medical University were enrolled. Cognitive functions in all subjects were assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Erythrocyte parameters were examined in all subjects. Analysis of variance was conducted to explore difference in both cognitive functions and erythrocyte parameters between alcohol-dependent patients and controls, and the influence of erythrocytes, mean corpuscular volume and hemoglobin on cognitive functions in alcohol-dependent group were examined using pearson correlation analysis. Results: There were significantly difference in immediate memory, visuospatial, language, attention, delayed memory and total score of RBANS between alcohol-dependent patients and controls (all, P<0.01). Alcohol-dependent group had lower erythrocytes and higher mean corpuscular volume compared to controls (both, P<0.01). There was a positive correlation between erythrocytes and delayed memory (P<0.01). Mean corpuscular volume was negatively correlation with language (P<0.05), delayed memory (P<0.01), and total score of RBANS (P<0.05). Conclusion: Male alcohol-dependent patients have cognitive impairments. Moreover, erythrocytes and mean corpuscular volume influence cognitive impairments in male alcohol-dependent patients.

Key words： alcohol dependence male cognitive functions erythrocyte parameters

Received: 22 April 2015

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I11/799

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