|
|
Clinical and pathological features of elder patients with idiopathic membranous nephropathy |
1.The First Clinical School, Wenzhou Medical University, Wenzhou, 325035; 2.Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015
|
|
Cite this article: |
CHEN Yu1,CHEN Xinxin2,HUANG Chaoxing2.. Clinical and pathological features of elder patients with idiopathic membranous nephropathy[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(10 ): 769-.
|
|
Abstract Objective: To investigate the clinical and pathological features of elder patients with idiopathic membranous nephropathy (IMN). Methods: One hundred and fifty patients with IMN were diagnosed by renal biopay in our hospital from Jun 2006 to Dec 2013, the relationship between clinical and pathological features were retrospectively analyzed on the basis of age, including older age group (≥60 s) 86 cases and jnvenile group (≤35 s) 64 cases. Results: Compared with jnvenile group, there were high incidence rates of hypertension, edema, renal insufficiency, diabetes and infections in the older age group. There were also significant statistical differences among course of disease, BUN, Scr, UA, Alb, TC, Fib, and Ccr in two groups. Most cases were classified as stage I or II membranous lesions in pathology. Compared with jnvenile group, there were high incidence rates in focal segment glomerulosclerosis, tubule-interstitial pathological changes, arterioles sclerosis and arteriole hyaline degeneration in the older age group. Conclusion: Elder IMN patients usually have complications with hypertension, diabetes, renal insufficiency, infections and tubule-interstitial and arterioles chronic pathological changes. More attentions should be paid to early diagnosis of IMN in elder patients, and take pertinence actions.
|
Received: 14 January 2015
|
|
|
|
|
[1] Zhang YL, Feng J, Li Y, et al. Analysis of clinical and pathological features of primary nephrotic syndrome in elderly patients[J]. Chin J Geriatr, 2013, 32(3): 843-846.
[2] 丁小强, 刘春风. 原发性膜性肾病研究进展[J]. 中国实用内科杂志, 2011, 2(2): 108-111.
[3] 邹万忠. 肾活检病理诊断标准指导意见(全国肾活检病理诊断研讨会)[J]. 中华肾脏病杂志, 2001, 17(4): 270-275.
[4] Roberts IS, Cook HT, Troyanov S, et al. Working Group of the International IgA Nephropathy Network and the Renal Pathology Society: The Oxford classification of IgA nephropathy: Pathology definitions, correlations, and reproducibility[J]. Kidney Int, 2009, 76(7): 546-556.
[5] Vendemia F, Gesualdo L, Schema FP, et al. Epidemiology of primary glomernlonephritis in the elderly: report from the Italian Registry of Renal Biopsy[J]. J Nephrel, 2001, 14(5): 340-352.
[6] Pontirelli C. Membranous nephropathy[J]. J Nephml, 2007,20(3): 268-287.
[7] 叶腾, 吕吟秋, 黄朝兴, 等. 温州市成人原发性肾小球疾病病理类型构成比20年演变[J]. 温州医科大学学报, 2015,45(8): 574-578.
[8] 王波, 刘志红, 吴燕, 等. 老年特发性膜性肾病患者的临床病理特点及其免疫系统功能的变化[J]. 肾脏病与透析肾移植杂志, 2009, 18(5): 423-429.
[9] 王艺萍, 王梅, 王素霞, 等. 老年人原发性膜性肾病肾小动脉病变的特点[J]. 中华老年医学杂志, 2008, 27(4): 244-247. |
|
|
|