高危型HPV载量及IFNγ基因多态性与LEEP术后CIN患者预后的相关性

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Abstract Objective: To investigate the association of interferon-gamma gene polymorphisms and the correlation between viral load remains and recidivation after loop ment for CIN patients. Methods: Performed gene analysis was used for detection of polymorphisms in interferon-gamma gene in 439 HPV positive patients undergone the LEEP treatment for CIN and 120 HPV negative normal controls, reviewed high-risk HPV DNA and cervix uterus TCT were reviewed in 3, 6, 9 and 12 months after treatment. Results: That the individuals with the TT genotype showed statistically significant had protection against HPV infection (OR=0.471, 95%CI=0.283～0.783; x2=8.702, P=0.003). That the individuals with the AA genotype showed statistically significant increased risk for HPV infection (OR=1.688, 95%CI=1.108～2.572; x2=6.005, P=0.014). The viral load before and after 3 months LEEP treatment of high-risk HPV was a risk factor of remains or recidivation after LEEP treatment (P<0.05). In the analysis of Kaplan-Meier, the cumulative HPV negative rates of AA and TT genotype exhibited significantly different (log-rank=15.414, P<0.001). The cumulative HPV negative rate of AA genotype was the lowest, the remains or recidivation rate of AA genotype was 45.65%. Conclusion: The viral load before and after 3 months LEEP treatment of high-risk HPV is related to CIN and the prognosis for CIN patients. Interferon-gamma gene rs2430561 polymorphisms affects the susceptibility to HPV infection. Women with AA genotype exhibited higher risk of infection and inclined to be continuous status and recurrence after HPV infection.

Key words： cervical intra-epithelial neoplasia interferon-gamma gene polymorphism human papilloma virus viral load

Received: 12 January 2015

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	CHEN Yan
	LIN Lin
	JIA Zhiqiang
	CHEN Niya

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I10 /738

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