长期小剂量罗红霉素治疗对中重度COPD患者气道局部免疫的影响

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1289 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To discusses effect on the airway local immune of long-term and low-dose roxithromycin and clinical significance of patients with moderately severe chronic obstructive pulmonary diseases (COPD). Methods: Sixty patients with moderately severe COPD were randomly divided into two groups (n=30): the roxithromycin and basic group. Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation combined with totropium Bromide Powder for Inhalation were used as the foundation treatment. The roxithromycin group combined with roxithromycin 150 mg, 1/d, oral. Both groups were followed up for a year, once every three months. Sixty cases of healthy check-up were as healthy controls. The CAT score, FEV, seurm lgG, lgA, lgM and induced sputum CD3+, CD4+, CD4+/CD8+, etc were tested and compared. Results: Compared with healthy group, the lgA, IgG of COPD group was decreased, serum induced sputum CD3+, CD4+, CD4+/CD8+ value was decreased, CD8+ increased (P<0.05). There was no significant difference between two groups of COPD (P>0.05). After three months, the lgA, IgG and induced sputum CD3+, CD4+, CD4+/CD8+ of roxithromycin group was increased, CD8+ decreased (P<0.05). CAT score decreased and FEV1 improved (P<0.05). Peak reached after six months of treatment (P<0.05). There was no significant difference both nine months and twelve months of treatment (P<0.05). In roxithromycin group, induced sputum CD4+/CD8+ and IgG, IgA, FEV1 had positive correlation (r=0.567, 0.587, 0.556, P<0.05), and the CAT score had negative correlation (r=-0.507, P<0.05). Conclusion: Long-term and low doses of roxithromycin use can improve the body airway partial immunity and quality of life of COPD patients. Long-term use of roxithromycin benefit is bigger.

Key words： chronic obstructive pulmonary diseases (COPD) roxithromycin T lymphocyte subsets induced sputum

Received: 08 January 2015

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LIU Xianbing
	LI Fang
	CHEN Xiaoping
	TIAN Mingqing
	YE Jianxian
	ZHU Lifen.

URL:

https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I10 /734

[1] Kobayashi Y, Wada H, Rossios C, et al. A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition[J]. J Pharmacol Exp Ther, 2013, 345(1):76-84.
[2] Simoens S, Laekeman G, Decramer M. Preventing COPD exacerbations with macrolides: a review and budget impact analysis[J]. Respir Med, 2013, 107(5): 637-648.
[3] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2007年修订版)[J]. 中华结核和呼吸杂志, 2007, 30(1): 8-17.
[4] 曾勉, 吴健锋, 谢灿茂, 等. 慢性阻塞性肺疾病急性加重期患者规范化痰诱导安全性的初步研究[J]. 中华结核和呼吸杂志, 2005, 28(4): 238-241.
[5] Spagnolo P, Fabbri LM, Bush A. Long-term macrolide treatment for chronic respiratory disease[J]. Eur Respir J, 2013, 42(1): 239-251.
[6] Uzun S, Djamin RS, Kluytmans J, et al. Influence of macrolide maintenance therapy and bacterial colonisation on exacerbation frequency and progression of COPD (CO-LUMBUS): study protocol for a randomised controlled trial [J]. Trials, 2012, 13: 82.
[7] Hodge S, Reynolds PN. Low-dose azithromycin improves phagocytosis of bacteria by both alveolar and monocytederived macrophages in chronic obstructive pulmonary disease subjects[J]. Eur Respir J, 2012, 40(2): 485-494.
[8] Pomares X, Montón C, Espasa M, et al. Long-term azithromycin therapy in patients with severe COPD and repeated exacerbations[J]. Eur Respir J, 2012, 40(2): 485-494.
[9] 刘健群, 刘雪白, 姜晶, 等. 长期小剂量罗红霉素对稳定期慢性阻塞性肺疾病的影响[J]. 中国慢性病预防与控制, 2010, 18(1): 66-68.
[10] 王众海, 戴元荣, 曾潍贤, 等. caveolin-1蛋白及ERK1/2信号途径在罗红霉素抑制哮喘气道平滑肌细胞增殖中的作用[J]. 温州医学院学报, 2013, 43(4): 228-231.
[11] Wilson AM, Leigh R, Hargreave FE, et al. Safety of sputum induction in moderate-to-severe smoking-related chronic obstructive pulmonary disease[J]. COPD, 2006, 3(2): 89-93.
[12] 王彦, 王长征, 林科雄. 哮喘患者吸入高渗盐水诱导痰的不良反应观察[J]. 第三军医大学学报, 2004, 26(7): 627-628.
[13] 刘贤兵, 陈传辉, 张伟, 等. 气温下降后慢性阻塞性肺疾病患者机体免疫情况的变化及意义[J]. 第三军医大学学报, 2010, 32(17): 1870-1874.