右美托咪定对腹腔镜胆囊切除术患者肝功能的影响

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Abstract Objective: To evaluate the effect of dexmedetomidine on hepatic function in patients undergone laparoscopic cholecystectomy with CO2 pneumoperitoneum. Methods: Sixty patients aged 18–60 years, whose pneumoperitoneum duration varied from 0.5 to 1 h and matched ASA I-II, were randomly divided into two groups: control group (group C, n=30) and dexmedetomidine group (group D, n=30). In group D, dexmedetomidine was infused intravenously at a rate of 1 μg•kg-1 for 10 min, followed by 0.3 μg•kg-1•h-1 until the end of the operation, while in group C equal volume of 0.9% sodium chloride solution was infused after trachea intubation. Peripheral vein blood samples were collected immediately before anesthesia (T0, baseline), 1 h (T1) and 24 h (T2) after pneumoperitoneum released for measurement of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), plasma IL-6, TNF-α, malondialdehyde (MDA) and superoxide dismutase (SOD) levels. Results: Compared with T0 point, the serum ALT, AST activities were significantly increased at T2 in both groups. Compared
with group C, the serum ALT, AST, plasma TNF-α and IL-6 were significantly descreased at T2 and the serum MDA was significantly descreased at T1, T2 and the levels of plasma SOD at T1 was significantly increased in group D (P<0.05). Conclusion: Hepatic injury in patients undergone laparoscopic cholecystectomy with CO2 pneumoperitoneum can be attenuated by dexmedetomidine via inhibiting inflammatory responses and lipid peroxidation.

Key words： dexmedetomidine laparoscopic cholecystectomy

Received: 06 March 2015

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	CHEN Li1
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	LU Bin2
	WU Ansheng2
	LI Jun1.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I9/687

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