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| The influence of different loading doses of Urapidil injection on blood pressure and the door-to-needle time in acute ischemic stroke |
Department of Neurology, Taizhou First People’s Hospital, Taizhou, 318020
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TAO Xiaoxiao,WANG Peng,JIN Yunlong, et al. The influence of different loading doses of Urapidil injection on blood pressure and the door-to-needle time in acute ischemic stroke[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(9): 671-.
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Abstract Objective: To observe the effect of different doses of Urapidil injection before thrombolysis in acute ischemic stroke on the blood pressure or door-to-needle time (DNT). Methods: Thirty-six cases in our hospital who were treated with Urapidil injection before intravenous t-PA treatment were retrospectively analyzed and were divided into 3 groups A, B, C according to the loading dose. Group A was with a loading dose of 5 mg Urapidil injection, Group B was with a loading dose of 12.5 mg, and Group C was with a loading dose of 25 mg. At last, shrinkage pressure (SBP), diastolic blood pressure (DBP), DNT and 3-month MRS score among the three groups were compared. Results: Compared to group A in which SBP was (173.27±6.92) mmHg and DBP (81.73±7.71) mmHg, the blood pressure of group B, with SBP (165.80±7.76) mmHg and DBP (80.93±6.95) mmHg, and group C, with SBP (154.80±10.69) mmHg and DBP (73.60±5.13) mmHg, decreased significantly (P<0.001). Compared to group A with (89.00±25.76) min, the DNT of group B with (76.73±20.20) min and group C with (73.10±14.15) min the door-to-needle time (DNT) significantly reduced (P<0.001). In addition, the percentage of MRS scores (0-1 points scale) after three months in group B (60.0%) was the highest among the three groups (P<0.001). Conclusion: Urapidil injection with the first load of 12.5 mg can effectively decrease blood pressure to standard as soon as possible with a better outcome.
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Received: 26 February 2015
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[1] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组. 中国急性缺血性脑卒中诊治指南2010[J]. 中华神经科杂志, 2010, 439(2): 146-153.
[2] Jauch EC, Saver JL, Adams HP Jr, et a1. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association[J]. Stroke,2013, 44(3): 870-947.
[3] Hacke W, Donnan G, Fieschi C, et a1. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials[J]. Lancet, 2004, 363(9411):768-774.
[4] Saver JL. Time is brain-quantified[J]. Stroke, 2006, 37(1):263-266.
[5] Tsivgoulis G, Kotsis V, Giannopoulos S. Intravenous thrombolysis for acute ischaemic stroke: Effective blood pressure control matters[J]. Int J Stroke, 2011, 6(2): 125-127.
[6] 兰清莲, 周成业, 王小同. 脑梗死后出血转化的危险因素分析[J]. 温州医科大学学报, 2014, 44(12): 877-881.
[7] Meretoja A, Keshtkaran M, Saver JL, et al. Stroke thrombolysis: save a minute, save a day[J]. Stroke, 2014, 45(4):1053-1058.
[8] 盐酸乌拉地尔注射液临床应用专家共识组. 盐酸乌拉地尔注射液临床应用专家共识[J]. 中华急诊医学杂志, 2013, 22(9): 960-966.
[9] Tsivgoulis G, Saqqur M, Sharma VK, et al. Association of pretreatment blood pressure with tissue plasminogen activator-induced arterial recanalization in acute ischemic stroke[J]. Stroke, 2007, 38(3): 961-966.
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