高级别宫颈鳞状上皮内病变患者宫颈环形电切术后病理阴性的相关因素分析

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Abstract Objective: To investigate the related factors of the negative pathological results of loop electrosurgical excision procedure (LEEP) in patients with high-grade cervical squamous intraepithelial lesions (CIN2-3). Methods: Totally 263 patients diagnosed as CIN2-3 by colposcopy-assisted biopsy and treated with LEEP in Jiaxing Maternity and Child Care Hospital from March 2011 to December 2012 were selected, and the relation of the negative pathological results of LEEP with age, cervical cytology, HPV load and pathological grading was analyzed. Results: Univariate analysis showed that low HPV load (<400 RLU/CO), low-grade of TCT, biopsy-confirmed CIN2 were associated with the prediction of the negative pathology of LEEP specimens (P=0.008, P=0.012, P=0.02), however, age was not related to the negative result of LEEP (P=0.172). Multivariate logistic analysis showed that low HPV load was the independent factor of the negative pathological results of LEEP (P= 0.019, OR=3.752, 95%CI 1.247～11.293). The area under ROC curve was 0.727 for three factors (HPV load, TCT and biopsy pathology diagnosis) predicting negative pathological result of LEEP. Conclusion: Low HPV load is related to the negative pathological results of LEEP. Combining low HPV load with low-grade of TCT and biopsy-confirmed CIN2 has a high predictive effect on negative pathological results of LEEP.

Key words： high-grade cervical squamous intraepithelial lesions loop electrosurgical excision procedure negative pathology

Received: 19 April 2015

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I9/665

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