慢性肾脏病患者血清脂联素水平的变化影响因素及其意义

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Abstract Objective: To explore the changes of the level of serum adiponectin (ADPN) in chronic kidney disease (CKD) patients in different periods, its influence factors and significance. Methods: One hundred and twelve patients with CKD were divided into five groups: 1, 2, 3, 4, 5 stages of CKD groups and 30 normal healthy persons as control group . To investigate serum creatinine (Scr), glomerular filtration rate (GFR). Serum ADPN, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6) were measured by Enzyme-linked immunoabsorbent assay (ELISA) and methyl dialdehyde (MDA) was examined with sulfo-barbituric acid. Results: Serum ADPN, hs-CRP, TNF-α, IL-6 and MDA in patients from CKD1 stage to CKD5 stage were significant higher than that in control group (P<0.05 or P<0.01), moreover, all index were increased step by step, existed significant difference between border upon groups (P<0.05 or P<0.01). There were significant positively correlations between the ADPN and hs-CRP (r=0.506), TNF-α(r=0.522), IL-6 (r=0.384), and MDA (r=0.437) (all P<0.01). Conclusion: With the progress of state of an illness of CKD patients, serum ADPN level remarkably gradually elevates. Among micro-inflammation, oxidative stress and decline of renal function induce each other, cooperation may be main causes of change of serum adiponectin.

Received: 11 September 2013

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	CHEN Huile1
	XU Changlong2
	XU Xiaojie3
	ZHOU Zhihong1

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2014/V44/I1/35

[1] Shehzad A, Iqbal W, Shehzad O, et al. Adiponectin: regula-tion of its production and its role in human diseases[J]. Hormones, 2012, 11(1): 8-20.
[2] Pham H, Utzschneider KM, de Boer IH. Measurement of insulin resistance in chronic kidney disease[J]. Curr Opin Nephrol Hypertens, 2011, 20(6): 640-646.
[3] Kishida K, Funahashi T, Shimomura I. Molecular mecha- nisms of diabetes and atherosclerosis: role of adiponectin [J]. Endocr Metab Immune Disord Drug Targets, 2012, 12 (2):118-131.
[4] Guebre-Egziabher F, Drai J, Fouque D, et al. Adiponectin and chronic kidney disease[J]. J Ren Nutr, 2007, 17(1): 9-12.
[5] Kollerits B, Fliser D, Heid IM, et al. Gender - specific asso- ciation of adiponectin as a predictor of progression of chronic kidney disease: the Mild to Moderate Kidney Disease Study [J]. Kidney Int, 2007, 71 (12): 1279-1286.
[6] Stenvinkel P. Adiponectin in chronic kidney disease: a com- plex and context sensitive clinical situation[J]. J Ren Nutr, 2011, 21(1): 82-86.
[7] National Kidney Foundation. K/DOQI clinical practice guide- lines for chronic kidney disease: evaluation, classification, and stratification[J]. Am J Kidney Dis, 2002, 39(2 Suppl 1): S1-266.
[8] 全国eGFR课题协作组. MDRD方程在我国慢性肾脏病患者中的改良和评估[J]. 中华肾脏病杂志, 2006, 22(10): 589-595.
[9] Zoccali C, Mallamaci F, Tripepi G, et al. Adiponectin, meta- bolic risk factors, and cardiovascular events among patients with end-stage renal disease[J]. J Am Soc Nephrol, 2002, 13 (2): 134-141.
[10] Guebre-Egziabher F, Bernhard J, Funahashi T, et al. Ad- iponectin in chronic kidney disease is related more to meta- bolic disturbances than to decline in renal function[J]. Nephrol Dial Transplant, 2005, 20(1): 129-134.
[11] Menon V, Li L, Wang X, et al. Adiponectin and mortality in patients with chronic kidney disease[J]. J Am Soc Nephrol, 2006, 17(9): 2599-2606.
[12] Chudek J, Adamczak M, Karkoszka H, et al. Plasma ad- iponectin concentration before and after successful kidney transplantation[J]. Transplant Proc, 2003, 35(6): 2186- 2189.
[13] Mitsnefes M, Kartal J, Khoury P, et al. Adiponectin in chil- dren with chronic kidney disease: role of adiposity and kid- ney dysfunction[J]. Clin J Am Soc Nephrol, 2007, 2(1): 46- 50.
[14] Yaturu S, Reddy RD, Rains J, et al. Plasma and urine levels of resistin and adiponectin in chronic kidney disease[J]. Cytokine, 2007, 37(1): 1-5.
[15] Yilmaz MI, Saglam M, Qureshi AR, et al. Endothelial dys- function in type-2 diabetics with early diabetic nephropathy is associated with low circulating adiponectin[J]. Nephrol Dial Transplant, 2008, 23(5): 1621-1627.
[16] Park SH, Carrero JJ, Lindholm B, et al. Adiponectin in chronic kidney disease has an opposite impact on protein energy wasting and cardiovascular risk: two sides of the same coin[J]. Clin Nephrol, 2009, 72(2): 87-96.
[17] Barazzoni R, BernardiA, Biasia F, et al. Low fat adiponectin expression is associated with oxidative stress in nondiabetic humans with chronic kidney disease-impact on plasma adiponectin concentration[J]. Am J Physiol Regul Integr Comp Physiol, 2007, 293(1): 47-54.

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