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| The correlative analysis of eNOS rs1799983 single-nucleotide polymorphisms and cerebral infarction |
Department of Neurology, Wenzhou Central Hospital, Wenzhou, 325000
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MAO Xinlei,HAN Liya,HUANG Xiangdong, et al. The correlative analysis of eNOS rs1799983 single-nucleotide polymorphisms and cerebral infarction[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(9): 652-.
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Abstract Objective: To investigate the relationship of eNOS rs1799983 single-nucleotide polymorphisms (SNP) and cerebral infarction. Methods: Data was prospectively collected from consecutive ischemic stroke inpatients in neurology department of our hospital from may 2014 to september 2014. Eighty-three large-artery atherosclerosis (LAA) patients and small-artery occlusion (SAO) patients in 100 patients were enrolled, according to the TOAST criteria. The control group was 91 subjects from the Medical Examination Center at the same period. Taqman probe technique was used for the detection of eNOS rs1799983 SNP. The clinical characteristics and eNOS rs1799983 SNP were compared between three groups. Results: As compared with the controls, there were statistically significant differences in percentage of HBP, smoking, drinking, high-density lipoprotein and cholesterol concentrations in LAA and SAO groups (P<0.01). The GG genotype was main genotype in three groups. Only 1 case TT genotype was observed in LAA group. The frequency of allele and genotype was not significantly difference in these three groups. Conclusion: It is suggested that there are similar risk factors in LAA and SAO patients. The eNOS rs1799983 SNP maybe unrelated to cerebral infarction.
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Received: 27 November 2014
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[1] 吕洋辉, 何松彬, 唐维国, 等. 头颈部大动脉粥样硬化与脑白质疏松相关性分析[J]. 温州医科大学学报, 2014, 44(12): 872-876.
[2] Bevan S, Traylor M, Adib-Samii P, et al. Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations[J]. Stroke,2012, 43(12): 3161-3167.
[3] Ikenouchi-Sugita A, Yoshimura R, Kishi T, et al. Three polymorphisms of the eNOS gene and plasma levels of metabolites of nitric oxide in depressed Japanese patients: a preliminary report[J]. Hum Psychopharmacol, 2011, 26(7): 531-534.
[4] Niu PP, Yang G, Zheng BK, et al. Relationship between endothelial nitric oxide synthase gene polymorphisms and ischemicstroke: a meta-analysis[J]. Acta Neurol Scand, 2013, 128(3): 202-212.
[5] Grewal RP, Dutra AV, Liao YC, et al. The intron 4c allele of the NOS3 gene is associated with ischemic stroke in African American[J]. BMC Med Genet, 2007, 10(8): 76.
[6] Guldiken B, Sipahi T, Guldiken S, et al. Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in Turkish patients with ischemic stroke[J]. Mol Biol Rep,2009, 36(6): 1539-1543.
[7] 章志量, 魏丹宏, 沈荣林, 等. 内皮型一氧化氮合酶基因G894T突变与脑梗死的相关研究[J]. 健康研究, 2009, 29(3): 180-183.
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