汉族男性注意缺陷多动障碍儿童执行功能与单胺氧化酶A基因活性相关分析

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Abstract Objective: To explore the relationship between polymorphism of MAOA gene activity and the executive function of attention-deficit hyperactivity disorder (ADHD). Methods: Choose 37 patients who was diagnosed as ADHD and 30 normal volunteers as controls. The executive function was evaluated using wisconsin card sorting test (WCST) and Stroop test. Taking peripheral blood and restriction fragment length polymorphism (RFLP) techniques were performed to detect MAOA 30 bp tandem repeats multiple of variable number, according to this repeats multiple, the case and control groups were divided into high and low activity group, respectively. Results: Group factor had significant effects on conceptual level, the number of completely classifications, the number of wrong answers, the number of continually mistakes, the number of continually answers in WCST; Group factor also had statistical significant differences on the complete time between A and C card in Stroop test (P<0.001), the time of interference effects also had statistically significant (P<0.05); MAOA gene activity factor had significant influence on conceptual level, the number of continually mistakes and the number of wrong answers had statistically significant on the difference of complete time in STROOP A card and C card (P<0.05), the time of interference effects also had statistically significant (P<0.05). There was no statistically significant in allele distribution of MAOA gene between the ADHD cases group and the control group (P>0.05). Conclusion: Our study find no relationship between MAOA-uVNTR allele distribution and ADHD, However, there maybe have relationship between MAOA polymorphism and part of the executive function.

Key words： attention-deficit hyperactivity disorder MAOA-uVNTR executive function stroop test wisconsin-sorting test

Received: 20 March 2015

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	WANG Weiqian
	DU Songmei
	YANG Chuang
	CHEN Hong
	ZHAO Yongzhong
	LIANG Yan
	LIN Haixi
	ZHANG Xiaoyan
	WANG Changlv
	WANG Meihao
	HE Jincai.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I9/641

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