精氨酸刺激试验对胰岛β细胞功能评估的临床价值

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Abstract Objective: To observe and assess the value of arginine stimulation test for testing the function of islet β-cell of patients with T2DM. Methods: The function of islet β-cell of 20 hospitalized patients with type 2 diabetes was evaluated using arginine stimulation test and standard bread meal. Assess the safety and efficiency of arginine stimulation test and estimate its clinical value for patients with T2DM. Results: There were no significant differences of blood glucose between each time point of arginine stimulation test (P=0.918); And the plasma glucose levels of 60 min and 120 min after the standard bread meal test were significantly higher (P=0.000). Insulin area under the curve, mean value, peak value of arginine stimulation test were positive correlation with insulin area under the curve of the standard bread meal test. Conclusion: Arginine stimulation test showed a superiority to assess islet function of patient with T2DM, with the advantages of less impact on blood glucose, simpler operation, and more safety. The last but not the least, the results of arginine stimulation test are consistent with the standard meal test’s, particularly for the first phase insulin secretion.

Key words： diabetes arginine stimulation test standard bread meal oral glucose tolerance test

Received: 05 March 2014

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	Articles by authors
	LIN Dini
	GU Xuemei
	SHEN Feixia
	SHI Mengte
	ZHU Qihan
	CHEN Xiong.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I8/604

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