温州市成人原发性肾小球疾病病理类型构成比20年演变

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Abstract Objective: To investigate the renal pathologic types of adults’ primary glomerular diseases (PGD) including primary nephrotic syndrome (PNS), and the changing spectrum in 20 years in Wenzhou. Methods: Totally 3 392 adult (≥18 years of age) cases of biopsy-proven primary glomerular diseases diagnosed in the period of 2000 to 2013 in the Department of Nephrology of our hospital were retrospectively investigated, the renal pathologic types of all cases were analyzed and another 553 PGD cases diagnosed in the period of 1993 to 1999 in the same department were analyzed as control. Results: ①All of the 3 392 cases of PGD patients, the median age was 37 (29, 48)y, male:female ratio=1:1. The leading PGD was IgA nephropathy (IgAN) (accounts for 59.5%), followed by membranous nephropathy (MN) (accounts for 16.5%) and minimal change disease (MCD) (accounts for 12.4%). MN was the most frequent finding in early stage of the elderly and elderly patients (accounts for 46.6% totally), whereas in young and middle-aged adults, IgAN was the commonest (accounts for 47.6% and 41.2%, respectively). ②Compared with those diagnosed in the period of 1993-1999, the incidence rate of MN was two-fold increased in 2000-2013 (accounts for 16.5% and 7.2%, respectively). Among 1 067 cases of PNS diagnosed in 2000-2013, the dominant renal histopathological finding was MN (accounts for 38.7%), followed by MCD (accounts for 38.3%), IgAN (accounts for 13.0%) and focal segmental glomerular sclerosis (FSGS, accounts for 6.2%). Conclusion: IgAN remains the commonest renal pathologic type of PGD which is correspondence with our previous study. MN become predominant among PNS and increases significantly in recent years. Without the change of indications for renal biopsy, the evolution of renal pathologic types in PGD over the past 20 years is probably related to the actual change of the kidney diseases in Wenzhou.

Key words： primary glomerular diseases pathologic types renal biopsy epidemiology

Received: 20 November 2014

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	YE Teng
	LV Yinqiu
	CHEN Bo
	LI Fanfan
	CHEN Xiaoqian
	HUANG Zhaoxing.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I8/574

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