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| Relationship between the methylenetetrahydrofolate reductase C677T, A1298C genetic polymorphisms and gastric cancer |
Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027
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XU Changlong,WANG Jianzhang,ZHENG Bo, et al. Relationship between the methylenetetrahydrofolate reductase C677T, A1298C genetic polymorphisms and gastric cancer[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2015, 45(5): 338-.
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Abstract Objective: To evaluate the association between methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C genetic polymorphisms and gastric cancer in Zhejiang Han nationality population. Methods: Select 112 cases of patients with gastric cancer, choose health check-up 218 cases as controls. The genetic polymorphisms of MTHFR (C677T and A1298C) were detected by PCR-RELP method. Results: There were no significant discrepancies of the mutational allele T and variant genotype (CT+TT) frequencies in the MTHFR C677T gene between the gastric cancer patients and the controls (34.82% vs 32.57% and 53.57% vs 52.75%, respectively, all P>0.05). The frequency of mutational allele C in MTHFR A1298C gene was significantly higher in gastric cancer patients than that in the controls (21.43% vs 12.39%, P=0.006, OR=1.929, 95%CI: 1.325~2.873). However, there were no significant discrepancies of the variant genotype frequencies (AC+CC) between the two groups (32.15% vs 36.24%, P>0.05). Conclusion: The mutational allele C in MTHFR A1298C gene may be associated with the susceptibility to gastric cancer in Zhejiang Han nationality population.
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Received: 03 January 2015
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