HLA-B*5801携带情况及其与别嘌醇过敏反应间的相关性

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Abstract Objective: To investigate the HLA-B*5801 carrying station and it’s correlation of allergic reactions caused by allopurinol of our hospitalized patients. Methods: The patients’ data from inpatient department were collected, then their HLA-B*5801 was analyzed and detected. Results: There were 100 cases determined the HLA-B*58 allele, and the HLA-B*5801 allele positive cases were 23, including 8 cases with allergic reaction. HLA-B*5801 negative one did not happen allergic reaction. Conclusion: Our patients carried high rate of HLA-B*5801, it will be more safe to detect the gene in time before use allopurinol. But the association between HLA-B*5801 and allergic reaction caused by allopurinol remains further research.

Key words： allopurinol renal insufficiency HLA-B*5801 allergic reaction

Received: 25 April 2014

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	YE Xiaolan1
	CHEN Chaosheng2
	XU Ren’ai1
	ZHANG Chunhong1
	PAN Xiaofeng1
	ZHANG Xiuhua1

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I2/143

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