白介素-6和降钙素原预测糖尿病足溃疡患者截肢的价值

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Abstract Objective: To determine clinical and laboratory factors that predict amputation surgery and to evaluate the predictive value of interleukin-6 (IL-6), and procalcitonin (PCT) in patients with diabetic foot ulcers (DFUs). Methods: Forty-five DFUs patients admitted to our hospital were consecutively enrolled. The patients’ demographics and wound characteristics were noted. IL-6 and PCT were measured at admission. Results: Twelve of the 45 patients (26.7%) eventually underwent lower extremity amputation. Compared to the non-amputation group, a previous history of amputation (P=0.003), the presence of gangrene (P=0.019), the Wagner grade (P=0.002), the lower extremity neuropathy (P=0.011), the IL-6 concentration (P=0.012), the white blood cell count (WBC) (P=0.033), and the erythrocyte sedimentation rate (ESR) (P=0.040) were significantly high in the amputation group. However, the PCT concentration was not significantly different. Conclusion: PCT failed to predict patients who will eventually require amputation and IL-6 may have predictive value for lower extremity amputation in patients with DFUs. Further studies are needed to confirm its predictive value in patients with DFUs.

Key words： diabetic foot interleukin-6 procalcitonin amputation

Received: 25 July 2014

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	HE Yinhui1
	XU Haiyan1
	YANG Ruhui2
	SUN Xia1
	CHEN Kai1

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I2/112

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