注意缺陷多动障碍亚型间脑fMRI低频振幅差异

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Abstract Objective: To study the different activities of amplitude of low frequency fluctuation (ALFF) among attention deficit hyperactivity disorder (ADHD) subtypes and the correlation between ALFF and behaviors. Methods: Seventy-eight participants were checked up by resting state functional magnetic resonance scanner, including 43 ADHD patients (15 of ADHD-I and 28 of ADHD-C) and 35 non-ADHD controls. The amplitude of low frequency fluctuation (ALFF) approach was used to analyse the brain function in resting state, and Conners children’s behavior scale was used to assess the behavior actuality. Results: Compared with the normal controls, ADHD-I showed decreased ALFF in left inferior frontal gyrus, right precuneus, and etc; ADHD-C showed decreased ALFF in left middle frontal gyrus, right precuneus, bilateral limbic lobe cingulate gyrus, and etc; and compared with ADHD-I, ADHD-C showed decreased ALFF in right cuneus, bilateral temporal lobe, limbic lobe cingulate gyrus, and etc. There were many brain regions of frontal/temporal lobe and cerebellum were correlated with Conners Index of Hyperactivity. All of the differences were statistically significant (P<0.05). Conclusion: Amplitude of low frequency fluctuation (ALFF) values of many brain regions were different among ADHD subtypes in rs-fMRI, and most of which were correlated with Conners Index of Hyperactivity.

Key words： attention deficit hyperactivity disorder subtype amplitude of low frequency fluctuation fMRI

Received: 08 December 2014

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I2/100

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