左旋肉碱对脂肪肝患者的干预效果

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Abstract Objective: To investigate the effects of L-carnitine on regulating blood lipids, transaminase, hepatic steatosis and fatty of patients with fatty liver. Methods: Dietary intervention with self-control method was adopted in 32 patients with fatty liver living one community. All participants take plus two oral L-carnitine tablets twice a day for three months. Blood lipids, transaminase, hepatic steatosis and fatty prior to intervention were tested and compared to those of after intervention in all participants. Results: After 3 months’ dietary intervention, ALT, AST, TBIL, TG, TC, LDL of patients were significantly decreased in contrast to those of prior intervention (P<0.01), while HDL was significantly increased (P<0.01). Body weight, body fat index, waistline, abdominal circumference, hips, waist-hip ratio of all participants were decreasing (P<0.01), respectively, meanwhile the subcutaneous fat thickness (arm, back, abdomen) also significantly decreased in contrast to that of prior intervention (P<0.01). Moreover, liver/spleen ratio was significantly increased after intervention (P<0.01), and no side effects was observed in all participants during the trial. Conclusion: As a dietary supplement, L-carnitine can improve the blood lipids, hepatic steatosis, reduce the patient’s transaminase and weight. The dietary intervention strategy is convenient and feasible for patients with fatty liver, and also easy for long-term use.

Key words： L-carnitine fatty liver blood lipids hepatic steatosis

Received: 10 April 2014

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	ZHANG Xiaohong
	DU Ling
	GU Weijun
	SONG Bin
	LIU Qiping
	TIAN Yi.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I1/61

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