芬吗通和补佳乐在冻融胚胎移植周期中的应用比较

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Abstract Objective: To compare the effect of Femoston and Progynova applied in the hormone replacement cycle for frozen-thawed blastocyst transfer. Methods: Two hundred and eight blastocyst FET cycles were analyzed retrospectively from July 2011 to December 2012. All cases were divided into two groups: 107 Femoston plus progesterone protocol group (group A), 173 Progynova plus progesterone protocol group (group B). Patient’s age, basic endocrine, endometrial thickness on the day of progesterone initiation, mean dosage and duration of estrogen per cycle, high quality embryo rate, mean number of embryo transferred per patient, implantation rate, clinical pregnancy rate, early abortion rate and ectopic pregnancy rate were compared between the two groups. Results: Before progesterone initiation, the duration of estrogen used in group A and group B was (9.80±2.81) d and (10.84±4.12) d and the dosage of estrogen used in group A and B was (15.55±10.42) mg and (58.80±24.57) mg respectively. The estradiol level on the day of progesterone initiation in group A and group B was (2 955.58± 1 983.94) pmol/L and (923.25±441.52) pmol/L, respectively. They all had significant differences (P<0.05). Clinical pregnancy rate were 57.94% (62/107) and 55.49% (96/173), respectively, and there was no statistically significant difference (P>0.05). Patient’s endometrial thickness on the day of progesterone initiation, high quality embryo rate, mean number of embryo transferred for per patient, implantation rate, clinical pregnancy rate, early abortion rate and ectopic pregnancy rate in these two groups had no significant different (P>0.05). Conclusion: In hormone replacement cycle for frozen-thawed embryo transfer, the use of Femoston can obtain the similar pregnancy rate compared with Progynova. So Femoston can be used as estrogen alone in blastocyst transplant recovery cycle.

Key words： frozen-thawed embryo transfer replacement cycle femoston endometrial preparation pregnancy

Received: 14 February 2014

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	WANG Peiyu
	ZHAO Junzhao
	JIN Congcong
	XIAO Shiquan
	LIN Jia
	ZHU Ruru.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2015/V45/I1/36

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