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| Correlation between serum neuron-specific enolase and cognitive dysfunction after acute stroke |
| WANG Hong1, WANG Liuqing2, WANG Zhen1, ZHANG Rongwen3, LEI Chenli3, LUAN Xiaoqian1. |
| 1.Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China; 2.Department of Neurology, People’s Hospital of Gaochun District, Nanjing 211300, China; 3.The First School of Medicine,Wenzhou Medical University, Wenzhou 325035, China |
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| Cite this article: |
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WANG Hong,WANG Liuqing,WANG Zhen, et al. Correlation between serum neuron-specific enolase and cognitive dysfunction after acute stroke[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2024, 54(6): 452-457.
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Abstract Objective: To explore the relationship between cognitive impairment in the acute stage of ischemic stroke and the levels of serum neuron-specific enolase (NSE) at admission. Methods: Subjects with acute ischemic stroke (AIS) were screened from the First Affiliated Hospital of Wenzhou Medical University from July 2017 to January 2023. Their cognition status was assessed by the Mini-Mental State Examination (MMSE) within the first month after stroke. Blood samples were obtained in the morning for measuring the levels of NSE, which were divided into four quartiles: Q1:≤11.00 ng/mL, Q2: >11.00-13.50 ng/mL, Q3: >13.50-17.00 ng/mL, and Q4: >17.00 ng/mL. To investigate the relationship between NSE and PSCI, binary logistic regression analysis was conducted. Additionally, a restricted cubic spline (RCS) model was employed to further investigate the connection between NSE and cognitive impairment in the acute stage of ischemic stroke.Results: The serum NSE levels were significantly higher in the PSCI group (P<0.05). With confounders adjusted,the risk of developing cognitive impairment was significantly higher for patients in the Q1, Q2 and Q4 quartiles compared with those in the Q3 quartile (P<0.05 for all). Additionally, the restricted cubic spline (RCS) model indicated that the risk of cognitive impairment in the acute stage of ischemic stroke escalated markedly with the increase of serum NSE levels once they surpassed the threshold of 17.69 ng/mL. Conclusion: Higher serum NSE levels were associated with cognitive impairment after stroke, which might aid in the early identification of highrisk patients and facilitate timely intervention.
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Received: 22 February 2024
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