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| Detection and result analysis of antimicrobial susceptibility in pulmonary tuberculosis patients co-infected with non-fermentative bacteria |
| SUN Haiqiong, PENG Lijun, CAI Long, FANG Tingting, DAI Lingshan, WEI Hui. |
| Clinical Laboratory Experiment Center, Hangzhou Red Cross Hospital, Hangzhou 310003, China |
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| Cite this article: |
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SUN Haiqiong,PENG Lijun,CAI Long, et al. Detection and result analysis of antimicrobial susceptibility in pulmonary tuberculosis patients co-infected with non-fermentative bacteria[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2024, 54(3): 228-232.
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Abstract Objective: To analyze the detection and drug susceptibility of non-fermenting bacterial infections in pulmonary tuberculosis patients, so as to provide evidence for clinical treatment. Methods: A totl of 394 hospitalized patients with pulmonary tuberculosis and concomitant non-fermenting bacterial infections treated at Hangzhou Red Cross Hospital from January 2018 to December 2022 were selected for the study. Following the standards set by the Clinical and Laboratory Standards Institute (CLI), the detection and drug susceptibility results of isolated non-fermenting bacteria were subjected to statistical analysis. Results: In 394 patients with tuberculosis co-infected with non-fermenting bacteria, a total of 401 strains of non-fermenting bacteria were isolated. The detection rate of non-fermenting bacteria in the Tuberculosis Department was around 30% from 2018 to 2022. The proportion of non-fermenting bacteria in the Tuberculosis Department/the overall hospital showed a yearly increase. Drug susceptibility results revealed that the resistance rate of Pseudomonas aeruginosa to imipenem and meropenem was 14.6% and 12.7% respectively; Acinetobacter baumannii to imipenem and meropenem exhibited the resistance rate of 51.3% and 60.0%, respectively. The resistance rate of Stenotrophomonas maltophilia to both minocycline and ticarcillin/clavulanate was below 10%. The resistance rate of Burkholderia cepacia to meropenem, cefotaxime, minocycline and trimethoprim-sulfamethoxazole ranged from 0% to 15.4%. Conclusion: The ratio of non-fermenting bacteria in the Tuberculosis Department/the overall hospital is increasing annually. Clinicians should pay attention to the detection and drug resistance monitoring of non-fermenting bacterial infections in pulmonary tuberculosis patients. Rational antibiotic use should be guided by drug susceptibility test results combined with clinical considerations.
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Received: 03 November 2023
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