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| VOSviewer-based visualization analysis on research hot topics and frontiers in immunotherapy for gastric cancer |
| CHEN Guijin, LIN Wei, ZHANG Chaohui, ZHU Bichun, ZHAO Lihong |
| Wenzhou Medical University Library and Periodical Press, Wenzhou 325035, China |
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CHEN Guijin,LIN Wei,ZHANG Chaohui, et al. VOSviewer-based visualization analysis on research hot topics and frontiers in immunotherapy for gastric cancer[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2023, 53(11): 923-929.
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Abstract Objective: To analyze the researches on the immunotherapy for gastric cancer and explore the research hot spots and frontiers. Methods: The literature on immunotherapy for gastric cancer published between January 1, 2018 and July 6, 2023 from the science citation index expanded database was searched. Web of Science,InCite, Excel and VOSviewer were used to analyze the countries, institutions, authors and keywords, and knowledge mapping was drawn. Results: A total of 878 articles were included, and the annual publication number showed a general upward trend, with China, Japan and the United States ranking the top three in the number of articles published. The top three institutions in order were the National Cancer Center - Japan, Fudan University,and Seoul National University. The co-occurrence analysis of the core authors showed that Japanese and South Korean researchers had close collaborative relationship in this field, while Chinese researchers had loose collaborative relationship. Frequency analysis and cluster analysis of keywords showed that immune checkpoint blocking was the main immunotherapy for gastric cancer. The hot topics and frontiers were biomarkers or models predicting the prognosis and immunotherapy response in gastric cancer, immune checkpoint inhibitors, especially PD-1 inhibitors, and their combination with chemotherapy/targeted drugs. Conclusion: The immunotherapy for gastric cancer has developed rapidly in the past six years. China is the main research country of the field, and we should continue to focus on the hot topics such as the combined therapy with immunotherapy, the prediction of the efficacy and prognosis of immunotherapy. Meanwhile, China could encourage and strengthen domestic andforeign cooperation to improve the research quality and promote the development in this field.
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Received: 20 August 2023
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