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| Effect of hyperuricemia on hemodynamics and left ventricular diastolic dysfunction in primary hypertension |
| FANG Danhong, WU Gaojun. |
| Department of Cardiology, Hypertension Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China |
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| Cite this article: |
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FANG Danhong,WU Gaojun.. Effect of hyperuricemia on hemodynamics and left ventricular diastolic dysfunction in primary hypertension[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2023, 53(10): 782-788，794.
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Abstract Objective: To analyze the effect of hyperuricemia (HU) on hemodynamic, and to explore the relationship between HU and left ventricular diastolic dysfunction in patients with uncontrolled primary hypertension. Methods: An observational study was conducted in 189 patients with uncontrolled hypertension who visited the First Affiliated Hospital of Wenzhou Medical University from August to December 2022. They were divided into hypertension with HU group (81 cases) and hypertension with non-HU group (108 cases). The demography, history of concomitant diseases, biochemical indicators, cardiac ultrasound indicators and noninvasive hemodynamic indicators were compared between the two groups. The relationship between HU and left ventricular diastolic dysfunction in hypertensive patients was investigated by multivariate logistic regression analysis. Results: The arterial stiffness index (ASI) in HU group was significantly lower than that in non-HU group (0.70±0.27 vs. 0.81±0.32, P=0.01). The hemodynamic phenotyping showed that the proportion of arterial vascular phenotype (high AS) and systemic vascular phenotype (high SVRI) in HU group and non-HU group was 60.49% vs. 65.74% and 80.56% vs. 85.18%, respectively, indicating no significant difference between the two groups (P>0.05). After adjusting the confounding covariates, multivariate Logistic regression analysis showed that HU was independently associated with left ventricular diastolic dysfunction in patients with hypertension (adjusted OR=5.05, 95%CI=1.87-13.58, P=0.001). Conclusion: HU affects the hemodynamic characteristics of primary hypertensive patients; HU is an independent risk factor for left ventricular diastolic dysfunction in hypertension.
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Received: 19 April 2023
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