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| The expression of long noncoding RNA lnc-CCDC33-1:1 in papillary thyroid carcinoma and its clinical significance |
| LI Pengping1, LAN Xiabin2, HUANG Yuqing1 |
| 1.Department of Thyroid and Breast Surgery,Xiaoshan Hospital Affiliated to Wenzhou Medical University, the First People’s Hospital of Xiaoshan District, Hangzhou 311201, China; 2.Department of Head and Neck Surgery, Cancer Hospital Affiliated to the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310005, China |
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| Cite this article: |
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LI Pengping,LAN Xiabin,HUANG Yuqing. The expression of long noncoding RNA lnc-CCDC33-1:1 in papillary thyroid carcinoma and its clinical significance[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2023, 53(2): 127-131.
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Abstract Objective: To evaluate the expression of lnc-CCDC33-1:1 in papillary thyroid carcinoma (PTC) and its clinical significance. Methods: A total of 120 patients with PTC admitted to the First People’s Hospital of Xiaoshan District, Hangzhou from November 2021 to March 2022 were selected. The expression levels of lnc-CCDC33-1:1 were detected in 120 PTC and 30 adjacent noncancerous thyroid tissues by quantitative realtime polymerase chain reaction. The relationships between the expression of lnc-CCDC33-1:1 in PTC and the clinicopathologic factors were analyzed both in our cohort and TCGA cohort. Receiver operating characteristic (ROC) curves were generated to assess the diagnostic value of lnc-CCDC33-1:1 as a biomarker for PTC. Results: The expression of lnc-CCDC33-1:1 was significantly upregulated in PTC tissues compared with adjacent noncancerous tissues (P<0.001). The ROC curves revealed that lnc-CCDC33-1:1 had a potential diagnostic value in predicting malignancy. The area under curves was 0.803 (95%CI=0.736-0.869, P<0.001). The local cohort showed that the expression of lnc-CCDC33-1:1 was correlated with PTC tumor size (P=0.048), extraglandular invasion (P=0.019), T stage (P=0.011), and lymph node metastasis (P=0.009). TCGA group data showed that the expression level of lnc-CCDC33-1:1 was correlated with PTC extraglandular invasion (P=0.036), and lymph node metastasis (P<0.001). Conclusion: The abnormally upregulated expression of lnc-CCDC33-1:1 in PTC is correlated with high-risk characteristics of PTC. Therefore, it may serve as a potential diagnostic biomarker or lnctreatment
target for PTC.
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Received: 18 April 2022
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