比较右美托咪定与曲马多预防围术期寒战效果的Meta分析

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Abstract Objective: To compare the effects of dexmedetomidine and tramadol in prevention of perioperative shivering and evaluate their side effects. Methods: All the randomized controlled trials referring to the comparison of dexmedetomidine and tramadol in prevention of perioperative shivering were searched in the domestic and foreign databases in recent five years. The enrolled published literatures were analyzed using Meta-analysis method with RevMan5.1 statistical analysis software. Results: Fourteen separate clinical randomized controlled trials including 854 cases were researched with the Meta-analysis. Objective responsiveness: the perioperative shivering rates of dexmedetomidine group were less than that of tramadol group (P=0.008). The RR values and 95%CI (confidence interval) were 0.60 (0.41~0.88). Adverse reactions: the incidence of nauses and vomiting were lower in the dexmedetomidine group than that in the tramadol group (P=0.008), the RR and 95%CI were 0.07 (0.03~0.14). The incidence of dizziness were lower in the dexmedetomidine group than that in the tramadol group (P=0.01), the RR and 95%CI were 0.28 (0.11~0.73). The funnel plots showed no significant publication bias in each indexes. Conclusion: The roles of prevention of perioperative shivering in dexmedetomidine group are superior to tramadol group. The incidence of adverse reactions are less in the dexmedetomidine group than that in the tramadol group.

Key words： dexmedetomidine tramadol perioperative shivering Meta-analysis

Received: 31 August 2014

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	ZHAO Xiyue1
	MIAO Jianxia1
	WANG Liangrong1
	JIANG Liuming1
	QIU Enyi2
	LIN Lina1.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2014/V44/I12/896

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