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| Application of contrast-enhanced ultrasound LI-RADS in the diagnosis of hepatocellular carcinoma in patients with occult hepatitis HBV infection |
| YAN Jianfei, CHEN Fanghong, LU Weiye, CHEN Zhihui, QIAN Xiao. |
Department of Ultrasound, Lishui Central Hospital, Lishui 323000, China |
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YAN Jianfei,CHEN Fanghong,LU Weiye, et al. Application of contrast-enhanced ultrasound LI-RADS in the diagnosis of hepatocellular carcinoma in patients with occult hepatitis HBV infection[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(10): 818-822.
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Abstract Objective: To investigate the diagnostic performance of contrast-enhanced ultrasound (CEUS) LI-RADS algorithm in the diagnosis of hepatocellular carcinoma (HCC) in patients with occult hepatitis B infection (OBI). Methods: A retrospective analysis was performed on 334 newly diagnosed hepatic focal lesions in OBI patients in Lishui Central Hospital from January 2018 to December 2021. Each nodule was assessed according to CEUS LI-RADS, and subgroup analysis was performed in patients with or without alpha-fetoprotein (AFP) >25 μg/L. The diagnostic performance of CEUS LI-RADS system for liver cancer was verified by sensitivity, specificity, precision, positive predictive value (PPV) and negative predictive value (NPV). Results: There were 120 HCC cases (36.0%), of which 4 (3.3%) were classified as LR-4, 7 (58.3%) as LR-5 and 46(38.3%) as LR-M. The sensitivity, specificity, precision, PPV and NPV of LR-5 class for predicting liver cancer was 58.3%, 88.8%, 77.8%, 74.5% and
79.2%, respectively. The sensitivity, specificity, precision, PPV and NPV of the LI-RADS diagnostic algorithm in OBI patients with AFP>25 μg/L was 63.3%, 80.0%, 65.7%, 95.0%and 26.7%, respectively. Given its high PPV, 13.0% (40/308) of OBI patients were highly suspected of HCC by CEUS. Conclusion: In OBI patients withFP>25 μg/L, using CEUS LR-5 as the diagnostic criteriion can help to confirm the diagnosis of HCC.
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Received: 14 April 2022
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