|
|
|
| The value of automated cardiac motion quantification technique in evaluating subclinical anthracyclineinduced cardiotoxicity in children with acute lymphoblastic leukemia |
| CHEN Kai1, WU Daozhu1, YE Wanding2, WANG Liang1, ZHOU Lin1 |
| 1.Department of Ultrasonography, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China; 2.Department of General Pediatrics, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China |
|
| Cite this article: |
|
CHEN Kai,WU Daozhu,YE Wanding, et al. The value of automated cardiac motion quantification technique in evaluating subclinical anthracyclineinduced cardiotoxicity in children with acute lymphoblastic leukemia[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(9): 718-723.
|
|
|
Abstract Objective: To investigate the value of automated cardiac motion quantification (aCMQ) in evaluating subclinical anthracycline-induced cardiotoxicity in children with acute lymphoblastic leukemia (ALL). Methods: Altogether 30 children with ALL who were treated with DVLD induced chemotherapy in the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University from November 2021 to January 2022 were selected as leukemia group. Echocardiography was performed before chemotherapy and 3 months later.Twenty-six healthy subjects were selected as the control group. Transthoracic echocardiography was performed to obtain left ventricular ejection fraction (LVEF), left ventricular short axis shortening (LVFS), E/A, E/e’, and e’/a’. The longitudinal strains of 2 chamber (AP2LS), 3 chamber (AP3LS), 4 chamber (AP4LS) and global longitudinal strain (LVGLS) were obtained by aCMQ technique. The annular strains of left ventricular short-axis basal segment
(SAXBCS), left ventricular short-axis intermediate segment (SAXMCS), left ventricular short-axis apical segment (SAXACS) and global circular strain (LVGCS) were compared and analyzed. Results: There were no significant differences in age between the leukemia group and the control group (P>0.05). There were no significant differences in LVEF, LVFS, E/A, E/e’ and e’/a’ between the control group, the pre-chemotherapy group and the post-chemotherapy group (P>0.05). The values of AP4LS, AP3LS, AP2LS, GLS, SAXBCS, SAXMCS, SAXACS and GCS in the pre-chemotherapy group were compared with those in the control group, with no significant difference (P>0.05). There was no significant difference in SAXBCS and SAXMCS between the group after chemotherapy and the control group before and after chemotherapy (P>0.05). The absolute values of AP4LS,AP3LS, AP2LS, GLS, SAXACS and GCS in the post-chemotherapy group were lower than those in the control group and the pre-chemotherapy group, with statistical difference (P<0.05). Conclusion: aCMQ can be used as a relatively accurate method for evaluating subclinical anthracycline-induced cardiotoxicity in children with ALL.
|
|
Received: 11 February 2022
|
| |
|
|
|
|
|
|
