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| Lymphoepithelioma-like carcinoma in the liver: clinicopathological features and MRI findings of 7 cases |
| GAO Yang1, SUN Hongming2, CHEN Chunmiao1, JI Jiansong1 |
| 1.Department of Radiology, Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; 2.Department of Pathology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China |
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| Cite this article: |
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GAO Yang,SUN Hongming,CHEN Chunmiao, et al. Lymphoepithelioma-like carcinoma in the liver: clinicopathological features and MRI findings of 7 cases[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(7): 575-576，581.
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Abstract Objective: To investigate the clinicopathological features and MRI findings of 7 cases with lymphoepithelioma-like carcinoma of liver. Methods: A retrospective analysis was carried out focusing on the clinicopathological features and MRI findings of 7 cases with lymphoepithelioma-like carcinoma of liver, who were confirmed by surgery and pathological examination in our hospital from December 2009 to December 2021. Results: Of 7 patients, there were 2 males and 5 females, with a median age of 54 years old. There were 4 cases of HBV (+), and all cases showed HCV (-), among which 1 case was accompanied by liver cirrhosis and elevated serum AFP level (389.7 ng/mL). Further pathological diagnosis reported 1 case of lymphoepithelioma like
hepatocellular carcinoma, and 6 cases of lymphoepithelioma like cholangiocarcinoma. Microscopically, there was infiltration of a large number of lymphocytes in the tumor tissue. EBER in situ hybridization was positive in 6 cases. MRI showed that the tumors with nodular appearance in 5 cases, regular morphology in 6 cases and clear boundary in 6 cases. T1WI showed low signal, while T2WI showed high signal. Meanwhile, 2 cases showed slightly high signal and 5 cases displayed significantly high signal on DWI. Furthermore, there were various enhancement patterns, including 3 cases of type I (wash-in and wash-out enhancement); 2 cases of type II (continuous annular enhancement); and 2 cases of type III (marginal filling enhancement). Capsular-like enhancement was visible in type I and II lesions. There was no abnormal enhancement around the tumor, no bile duct dilatation or hepatic capsule retraction in all lesions. Conclusion: Clinically rare, lymphoepithelioma-like carcinoma of liver has relatively good prognosis with certain pathological characteristics. MRI manifestations are mainly rounded nodules with various enhancement, mostly capsular-like enhancement.
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