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| Application of rapid on-site evaluation combined with radial-endobronchial ultrasound of transbronchial cryobiopsy in the diagnosis of diffuse lung diseases |
| CHEN Weizhuang1, LI You1, WANG Hui1, ZHOU Yingyan1, WANG Guoan1, Shen Shimo1, Chen Jinping2, WU Shibo1, WU Hongcheng1 |
| CHEN Weizhuang1, LI You1, WANG Hui1, ZHOU Yingyan1, WANG Guoan1, Shen Shimo1, Chen Jinping2, WU Shibo1, WU Hongcheng1 |
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| Cite this article: |
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CHEN Weizhuang,LI You,WANG Hui, et al. Application of rapid on-site evaluation combined with radial-endobronchial ultrasound of transbronchial cryobiopsy in the diagnosis of diffuse lung diseases[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(2): 132-138.
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Abstract Objective: To investigate the feasibility and safety of transbronchial cryobiopsy (TBCB) in the diagnosis of diffuse lung diseases (DLD) with assistance of Rapid On-Site Evaluation (ROSE) and Radial-endobronchial ultrasound (R-EBUS). Methods: Patients with diffuse lung disease who underwent TBCB from June 2019 to September 2021 were enrolled and their clinical characteristics, pathological types, biopsy characteristics and complications were recorded. Results: A total of 52 patients were included in the study, 20 males and 32 females, with a mean age of (54.0±13.2) years; a total of 182 cryobiopsies, (3.50±1.00) cryobiopsies per patient; the mean size of tissues was (13.69±4.72) mm2, ranging 6-30 mm2. According to the 2013 ATS/ERS classification standard for the interstitial lung diseases, there were 26 cases of known etiology (50.00%), 13 cases of idiopathic interstitial pneumonia (25.00%), 4 case of granulomatous lesions (7.69%) and 9 cases of other types (17.31%). In terms of complications, none or minimal bleeding occurred in 20 patients, mild bleeding in 21 patients, moderate bleeding in 11 patients. No severe bleeding occurred. Pneumothorax occurred in 2 patients, acute left heart failure in 1 patient and hypoxemia in 1 patient. The median post-TBCB hospital day was 6 (1.00, 6.00) days. Conclusion: The combined application of ROSE and R-EBUS in TBCB is feasible and safe in the diagnosis of DLD.
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