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| Changes of kidney disease spectrum in Wenzhou area in recent 10 years: a retrospective study of 5 114 biopsy-proven cases |
| Lin Sishi 1, 2, Chen Bo 1, 2, Zhou Ying 1, 2, You Xiaohan 1, 2, Zhang Jianna 1, 2, Chen Xinxin 1, 2, Ding Xiaokai 1, 2, Zhang Ji 1, 2, Chen Chaosheng 1, 2. |
| 1.Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China; 2.Institute of Chronic Kidney Disease, Wenzhou Medical University, Wenzhou 325035, China |
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Lin Sishi,Chen Bo,Zhou Ying, et al. Changes of kidney disease spectrum in Wenzhou area in recent 10 years: a retrospective study of 5 114 biopsy-proven cases[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(1): 15-22.
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Abstract Objective: To analyze the composition and epidemiological trend of kidney disease spectrum in Wenzhou area in the past decade. Methods: A total of 5 114 biopsy-proven cases diagnosed in the Division of Kidney Pathology the First Affiliated Hospital of Wenzhou Medical University, from October 2009 to September 2019, were included in this study. They were divided on a 5-year basis as group 1 (October 2009 to September 2014) and group 2 (October 2014 to September 2019), with an analysis of the composition and evolution of kidney diseases. Results: The patients’ mean age at biopsy increased with time, and the proportion of the elderly patients
who received renal biopsy increased from 7.70% to 20.36%. Compared with group 1, group 2 had significantly increased the proportion of membranous nephropathy (MN) (24.3% vs. 36.8%, P<0.001), especially in the 45-59 age category. The secondary glomerular disease (SGD) mainly composed of immune-mediated diseases (55.0%),tumor-associated or metabolic diseases (33.8%) and infection-associated diseases (3.7%). Compared with group1, group 2 had nearly doubled proportion of tumor-associated or metabolic diseases (24.0% vs. 44.4%, P<0.001).Conclusion: In the past 10 years, the kidney disease spectrum in Wenzhou area has changed significantly. The proportion of MN was significantly increased and has become the most common PGD among middle-aged and elderly patients. In addition, the proportion of tumor-associated or metabolic diseases such as diabetic nephropathy and renal amyloidosis increased significantly.
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Received: 26 July 2021
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